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  1. Early detection of individuals at risk for Alzheimer’s disease (AD) is highly important. Amyloid accumulation is an early pathological AD event, but the genetic association with known AD risk variants beyond the

    Authors: Emma S. Luckett, Yasmina Abakkouy, Mariska Reinartz, Katarzyna Adamczuk, Jolien Schaeverbeke, Sare Verstockt, Steffi De Meyer, Koen Van Laere, Patrick Dupont, Isabelle Cleynen and Rik Vandenberghe
    Citation: Alzheimer's Research & Therapy 2022 14:138
  2. This study aimed to identify cases of potential prodromal DLB in very late-onset schizophrenia-like psychosis (VLOSLP), using indicative biomarkers of dementia with Lewy bodies (DLB), and to evaluate the chara...

    Authors: Hideki Kanemoto, Yuto Satake, Takashi Suehiro, Daiki Taomoto, Fuyuki Koizumi, Shunsuke Sato, Tamiki Wada, Keiko Matsunaga, Eku Shimosegawa, Mamoru Hashimoto, Kenji Yoshiyama and Manabu Ikeda
    Citation: Alzheimer's Research & Therapy 2022 14:137
  3. Alzheimer’s disease (AD) is characterized by a reorganization of brain activity determining network hyperexcitability and loss of synaptic plasticity. Precisely, a dysfunction in metabotropic GABAB receptor signa...

    Authors: Alejandro Martín-Belmonte, Carolina Aguado, Rocío Alfaro-Ruiz, Ana Esther Moreno-Martínez, Luis de la Ossa, Ester Aso, Laura Gómez-Acero, Ryuichi Shigemoto, Yugo Fukazawa, Francisco Ciruela and Rafael Luján
    Citation: Alzheimer's Research & Therapy 2022 14:136
  4. Aquaporin-4 (AQP4) is a channel protein that plays a fundamental role in glymphatic system, a newly described pathway for fluid exchange in the central nervous system, as well as a central figure in a fascinat...

    Authors: Andrea Arighi, Marina Arcaro, Giorgio Giulio Fumagalli, Tiziana Carandini, Anna Margherita Pietroboni, Luca Sacchi, Chiara Fenoglio, Maria Serpente, Federica Sorrentino, Giovanni Isgrò, Federico Turkheimer, Elio Scarpini and Daniela Galimberti
    Citation: Alzheimer's Research & Therapy 2022 14:135
  5. Vascular disease is a known risk factor for Alzheimer’s disease (AD). Endothelial dysfunction has been linked to reduced cerebral blood flow. Endothelial nitric oxide synthase pathway (eNOS) upregulation is kn...

    Authors: Elizabeth Degrush, Mohammed Salman Shazeeb, David Drachman, Zeynep Vardar, Clifford Lindsay, Matthew J. Gounis and Nils Henninger
    Citation: Alzheimer's Research & Therapy 2022 14:134
  6. Sex is increasingly recognized as a significant factor contributing to the biological and clinical heterogeneity in AD. There is also growing evidence for the prominent role of DNA methylation (DNAm) in Alzhei...

    Authors: Tiago C. Silva, Wei Zhang, Juan I. Young, Lissette Gomez, Michael A. Schmidt, Achintya Varma, X. Steven Chen, Eden R. Martin and Lily Wang
    Citation: Alzheimer's Research & Therapy 2022 14:133
  7. Quality of life (QoL) is an important outcome from the perspective of patients and their caregivers, in both dementia and pre-dementia stages. Yet, little is known about the long-term changes in QoL over time....

    Authors: Arenda Mank, Judith J. M. Rijnhart, Ingrid S. van Maurik, Linus Jönsson, Ron Handels, Els D. Bakker, Charlotte E. Teunissen, Bart N. M. van Berckel, Argonde C. van Harten, Johannes Berkhof and Wiesje M. van der Flier
    Citation: Alzheimer's Research & Therapy 2022 14:132
  8. Authors: Fatemah A. Sakr, Michel J. Grothe, Enrica Cavedo, Irina Jelistratova, Marie-Odile Habert, Martin Dyrba, Gabriel Gonzalez-Escamilla, Hugo Bertin, Maxime Locatelli, Stephane Lehericy, Stefan Teipel, Bruno Dubois and Harald Hampel
    Citation: Alzheimer's Research & Therapy 2022 14:131

    The original article was published in Alzheimer's Research & Therapy 2019 11:15

  9. Immune system dysregulation plays a vital role in the pathogenesis of neurodegenerative diseases, even considered to be as important as classical pathological protein aggregation assumption. However, the assoc...

    Authors: Ya-Ru Zhang, Liu Yang, Hui-Fu Wang, Bang-Sheng Wu, Shu-Yi Huang, Wei Cheng, Jian-Feng Feng and Jin-Tai Yu
    Citation: Alzheimer's Research & Therapy 2022 14:130
  10. Cortical deposition of β-amyloid (Aβ) plaque is one of the main hallmarks of Alzheimer’s disease (AD). While Aβ positivity has been the main concern so far, predicting whether Aβ (−) individuals will convert t...

    Authors: Chae Jung Park, Younghoon Seo, Yeong Sim Choe, Hyemin Jang, Hyejoo Lee and Jun Pyo Kim
    Citation: Alzheimer's Research & Therapy 2022 14:129
  11. Chronic inflammation is a central feature of several forms of dementia. However, few details on the associations of blood-based inflammation-related proteins with dementia incidence have been explored yet.

    Authors: Kira Trares, Megha Bhardwaj, Laura Perna, Hannah Stocker, Agnese Petrera, Stefanie M. Hauck, Konrad Beyreuther, Hermann Brenner and Ben Schöttker
    Citation: Alzheimer's Research & Therapy 2022 14:128
  12. Measurements of the amyloid-β (Aβ) 42/40 ratio in blood plasma may support the early diagnosis of Alzheimer’s disease and aid in the selection of suitable participants in clinical trials. Here, we compared the...

    Authors: Hans-W. Klafki, Jonathan Vogelgsang, Ekaterina Manuilova, Chris Bauer, Alexander Jethwa, Hermann Esselmann, Anke Jahn-Brodmann, Dirk Osterloh, Ingolf Lachmann, Benedict Breitling, Carolin Rauter, Niels Hansen, Caroline Bouter, Stefan Palme, Johannes Schuchhardt and Jens Wiltfang
    Citation: Alzheimer's Research & Therapy 2022 14:127
  13. The COVID-19 pandemic may worsen the mental health of people reporting subjective cognitive decline (SCD) and therefore their clinical prognosis. We aimed to investigate the association between the intensity o...

    Authors: Muge Akinci, Gonzalo Sánchez-Benavides, Anna Brugulat-Serrat, Cleofé Peña-Gómez, Eleni Palpatzis, Mahnaz Shekari, Carme Deulofeu, Sherezade Fuentes-Julian, Gemma Salvadó, José Maria González-de-Echávarri, Marc Suárez-Calvet, Carolina Minguillón, Karine Fauria, José Luis Molinuevo, Juan Domingo Gispert, Oriol Grau-Rivera…
    Citation: Alzheimer's Research & Therapy 2022 14:126
  14. Older individuals with subjective cognitive decline (SCD) perceive that their cognition has declined but do not show objective impairment on neuropsychological tests. Individuals with SCD are at elevated risk ...

    Authors: Tim Whitfield, Harriet Demnitz-King, Marco Schlosser, Thorsten Barnhofer, Eric Frison, Nina Coll-Padros, Sophie Dautricourt, Florence Requier, Marion Delarue, Julie Gonneaud, Olga M. Klimecki, Antoine Lutz, Léo Paly, Eric Salmon, Ann-Katrin Schild, Zuzana Walker…
    Citation: Alzheimer's Research & Therapy 2022 14:125
  15. Biomarkers for amyloid, tau, and neurodegeneration (ATN) have predictive value for clinical progression, but it is not clear how individuals move through these stages. We examined changes in ATN profiles over ...

    Authors: Jarith L. Ebenau, Denise Visser, Lior A. Kroeze, Mardou S. S. A. van Leeuwenstijn, Argonde C. van Harten, Albert D. Windhorst, Sandeep V. S. Golla, Ronald Boellaard, Philip Scheltens, Frederik Barkhof, Bart N. M. van Berckel and Wiesje M. van der Flier
    Citation: Alzheimer's Research & Therapy 2022 14:124
  16. Adults with Down syndrome are at an ultra-high risk of developing early-onset Alzheimer’s disease. Episodic memory deficits are one of the earliest signs of the disease, but their association with regional bra...

    Authors: Bessy Benejam, Mateus Rozalem Aranha, Laura Videla, Concepción Padilla, Silvia Valldeneu, Susana Fernández, Miren Altuna, Maria Carmona-Iragui, Isabel Barroeta, Maria Florencia Iulita, Víctor Montal, Jordi Pegueroles, Alexandre Bejanin, Sandra Giménez, Sofía González-Ortiz, Sebastián Videla…
    Citation: Alzheimer's Research & Therapy 2022 14:123
  17. Subjective cognitive decline (SCD) is a putative Alzheimer’s disease (AD) precursor without objective neuropsychological deficits. The hippocampus plays an important role in cognitive function and emotional re...

    Authors: Qiang Wang, Ben Chen, Xiaomei Zhong, Le Hou, Min Zhang, Mingfeng Yang, Zhangying Wu, Xinru Chen, Naikeng Mai, Huarong Zhou, Gaohong Lin, Si Zhang and Yuping Ning
    Citation: Alzheimer's Research & Therapy 2022 14:122
  18. The clinical features of Alzheimer’s disease (AD) vary substantially depending on whether the onset of cognitive deficits is early or late. The amount and distribution patterns of tau pathology are thought to ...

    Authors: Wha Jin Lee, Hanna Cho, Min Seok Baek, Han-Kyeol Kim, Jae Hoon Lee, Young Hoon Ryu, Chul Hyoung Lyoo and Joon-Kyung Seong
    Citation: Alzheimer's Research & Therapy 2022 14:121
  19. Core cerebrospinal fluid (CSF) amyloid and tau biomarker assessment has been recommended to refine the diagnostic accuracy of Alzheimer’s disease. Lumbar punctures (LP) are invasive procedures that might induc...

    Authors: Pauline Courtois-Amiot, Anaïs Cloppet-Fontaine, Aurore Poissonnet, Elodie Benit, Muriel Dauzet, Agathe Raynaud-Simon, Claire Paquet and Matthieu Lilamand
    Citation: Alzheimer's Research & Therapy 2022 14:120
  20. Repetitive head injury in contact sports is associated with cognitive, neurobehavioral, and motor impairments and linked to a unique neurodegenerative disorder: chronic traumatic encephalopathy (CTE). As the c...

    Authors: Suzan van Amerongen, Dewi K. Caton, Rik Ossenkoppele, Frederik Barkhof, Petra J. W. Pouwels, Charlotte E. Teunissen, Annemieke J. M. Rozemuller, Jeroen J. M. Hoozemans, Yolande A. L. Pijnenburg, Philip Scheltens and Everard G. B. Vijverberg
    Citation: Alzheimer's Research & Therapy 2022 14:119
  21. Approximately a third of frontotemporal dementia (FTD) is genetic with mutations in three genes accounting for most of the inheritance: C9orf72, GRN, and MAPT. Impaired synaptic health is a common mechanism in al...

    Authors: Aitana Sogorb-Esteve, Johanna Nilsson, Imogen J. Swift, Carolin Heller, Martina Bocchetta, Lucy L. Russell, Georgia Peakman, Rhian S. Convery, John C. van Swieten, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce Jr., Fermin Moreno, Matthis Synofzik…
    Citation: Alzheimer's Research & Therapy 2022 14:118
  22. Alzheimer’s disease (AD) is foremost characterized by β-amyloid (Aβ)-extracellular plaques, tau-intraneuronal fibrillary tangles (NFT), and neuroinflammation, but over the last years it has become evident that...

    Authors: Dovilė Pocevičiūtė, Cristina Nuñez-Diaz, Bodil Roth, Shorena Janelidze, Andreas Giannisis, Oskar Hansson and Malin Wennström
    Citation: Alzheimer's Research & Therapy 2022 14:117
  23. Parkinson’s disease (PD) is one of the most common neurodegenerative diseases in the aging population. Previous literature has reported thinning of the retinal nerve fiber layer, ganglion cell layer, inner ple...

    Authors: Yifan Zhang, Li Yang, Yuzhu Gao, Dan Zhang, Yunhan Tao, Hanyue Xu, Yi Chen, Yanming Xu and Ming Zhang
    Citation: Alzheimer's Research & Therapy 2022 14:116
  24. Low levels of plasma apolipoprotein E (apoE) and presence of the APOE ε4 allele are associated with an increased risk of Alzheimer’s disease (AD). Although the increased risk of AD in APOE ε4-carriers is well-est...

    Authors: Andreas Giannisis, Asma Al-Grety, Henrik Carlsson, Kalicharan Patra, Daniel Twohig, Sigrid Botne Sando, Camilla Lauridsen, Guro Berge, Gøril Rolfseng Grøntvedt, Geir Bråthen, Linda R. White, Kim Kultima and Henrietta M. Nielsen
    Citation: Alzheimer's Research & Therapy 2022 14:115
  25. The 2018 NIA-AA Alzheimer’s Disease (AD) Research Framework states that subtle cognitive decline in cognitively unimpaired individuals can be measured by subjective reports or evidence of objective decline on ...

    Authors: Kelsey R. Thomas, Alexandra J. Weigand, Lauren C. Edwards, Emily C. Edmonds, Katherine J. Bangen, Gema Ortiz, Kayla S. Walker and Mark W. Bondi
    Citation: Alzheimer's Research & Therapy 2022 14:114
  26. Neuropsychological testing plays a cardinal role in the diagnosis and monitoring of Alzheimer’s disease. A major concern is represented by the heterogeneity of the neuropsychological batteries currently adopte...

    Authors: Francesca Conca, Valentina Esposito, Francesco Rundo, Davide Quaranta, Cristina Muscio, Rosa Manenti, Giulia Caruso, Ugo Lucca, Alessia Antonella Galbussera, Sonia Di Tella, Francesca Baglio, Federica L’Abbate, Elisa Canu, Valentina Catania, Massimo Filippi, Giulia Mattavelli…
    Citation: Alzheimer's Research & Therapy 2022 14:113

    The Correction to this article has been published in Alzheimer's Research & Therapy 2023 15:104

    The Correction to this article has been published in Alzheimer's Research & Therapy 2023 15:63

  27. Patient stratification is the division of a patient population into distinct subgroups based on the presence or absence of particular disease characteristics. As patient stratification can be used to account f...

    Authors: Carla Abdelnour, Federica Agosta, Marco Bozzali, Bertrand Fougère, Atsushi Iwata, Ramin Nilforooshan, Leonel T. Takada, Félix Viñuela and Martin Traber
    Citation: Alzheimer's Research & Therapy 2022 14:112
  28. Mild cognitive impairment (MCI) is an early stage of cognitive decline which could develop into dementia. An early detection of MCI is a crucial step for timely prevention and intervention. Recent studies have...

    Authors: Natthanan Ruengchaijatuporn, Itthi Chatnuntawech, Surat Teerapittayanon, Sira Sriswasdi, Sirawaj Itthipuripat, Solaphat Hemrungrojn, Prodpran Bunyabukkana, Aisawan Petchlorlian, Sedthapong Chunamchai, Thiparat Chotibut and Chaipat Chunharas
    Citation: Alzheimer's Research & Therapy 2022 14:111
  29. Patients and caregivers express a desire for accurate prognostic information about time to institutionalization and mortality. Previous studies predicting institutionalization and mortality focused on the deme...

    Authors: Arenda Mank, Ingrid S. van Maurik, Judith J. M. Rijnhart, Els D. bakker, Vincent Bouteloup, Lisa Le Scouarnec, Charlotte E. Teunissen, Frederik Barkhof, Philip Scheltens, Johannes Berkhof and Wiesje M. van der Flier
    Citation: Alzheimer's Research & Therapy 2022 14:110
  30. The differentiation of Lewy body dementia from other common dementia types clinically is difficult, with a considerable number of cases only being found post-mortem. Consequently, there is a clear need for ine...

    Authors: Jack L. Jennings, Luis R. Peraza, Mark Baker, Kai Alter, John-Paul Taylor and Roman Bauer
    Citation: Alzheimer's Research & Therapy 2022 14:109
  31. In fewer than 1% of patients, AD is caused by autosomal dominant mutations in either the presenilin 1 (PSEN1), presenilin 2 (PSEN2), or amyloid precursor protein (APP) genes. The full extent of familial AD and fr...

    Authors: Leonel Tadao Takada, Carmen Aláez-Verson, Bhagyashri D. Burgute, Ricardo Nitrini, Ana Luisa Sosa, Raphael Machado Castilhos, Marcia Fagundes Chaves, Erika-Mariana Longoria, Karol Carrillo-Sánchez, Sonia Maria Dozzi Brucki, Luis Leonardo Flores-Lagunes, Carolina Molina, Marcos Jimenez Olivares, Ellen Ziegemeier, Jennifer Petranek, Alison M. Goate…
    Citation: Alzheimer's Research & Therapy 2022 14:108
  32. Early and accurate diagnosis of Alzheimer’s disease (AD) is essential for disease management and therapeutic choices that can delay disease progression. Machine learning (ML) approaches have been extensively u...

    Authors: Vasco Sá Diogo, Hugo Alexandre Ferreira and Diana Prata
    Citation: Alzheimer's Research & Therapy 2022 14:107
  33. This study investigated plasma biomarkers for neuroinflammation associated with Alzheimer’s disease (AD) in subjects with preclinical AD compared to healthy elderly. How these biomarkers behave in patients wit...

    Authors: Samantha Prins, Marieke L. de Kam, Charlotte E. Teunissen and Geert Jan Groeneveld
    Citation: Alzheimer's Research & Therapy 2022 14:106
  34. The ability of 18F-PI-2620 PET to measure the spatial distribution of tau pathology in Alzheimer’s disease (AD) has been demonstrated in previous studies. The objective of this work was to evaluate tau deposition...

    Authors: Santiago Bullich, Andre Mueller, Susan De Santi, Norman Koglin, Stephen Krause, June Kaplow, Michio Kanekiyo, Núria Roé-Vellvé, Audrey Perrotin, Aleksandar Jovalekic, David Scott, Michelle Gee, Andrew Stephens and Michael Irizarry
    Citation: Alzheimer's Research & Therapy 2022 14:105
  35. The S209F variant of Abelson Interactor Protein 3 (ABI3) increases risk for Alzheimer’s disease (AD), but little is known about its function in relation to AD pathogenesis.

    Authors: Kristen R. Ibanez, Karen N. McFarland, Jennifer Phillips, Mariet Allen, Christian B. Lessard, Lillian Zobel, Elsa Gonzalez De La Cruz, Shivani Shah, Quan Vo, Xue Wang, Zachary Quicksall, Daniel Ryu, Cory Funk, Nilüfer Ertekin-Taner, Stefan Prokop, Todd E. Golde…
    Citation: Alzheimer's Research & Therapy 2022 14:104
  36. The deposition of β-amyloid (Aβ) in the brain plays a major role in the pathogenesis of Alzheimer’s disease (AD). Aβ is generated via amyloid precursor protein (APP) cleavage through the amyloidogenic pathway....

    Authors: Yaqi Wang, Yuting Cui, Jing Liu, Qiao Song, Min Cao, Yuli Hou, Xiaomin Zhang and Peichang Wang
    Citation: Alzheimer's Research & Therapy 2022 14:103
  37. Cognitive reserve and resilience are terms used to explain interindividual variability in maintenance of cognitive health in response to adverse factors, such as brain pathology in the context of aging or neur...

    Authors: Jeremy A. Elman, Jacob W. Vogel, Diana I. Bocancea, Rik Ossenkoppele, Anna C. van Loenhoud, Xin M. Tu and William S. Kremen
    Citation: Alzheimer's Research & Therapy 2022 14:102
  38. Neuronal hyperexcitability and inhibitory interneuron dysfunction are frequently observed in preclinical animal models of Alzheimer’s disease (AD). This study investigates whether these microscale abnormalitie...

    Authors: Anne M. van Nifterick, Alida A. Gouw, Ronald E. van Kesteren, Philip Scheltens, Cornelis J. Stam and Willem de Haan
    Citation: Alzheimer's Research & Therapy 2022 14:101
  39. YKL-40 (Chitinase 3-like I) is increased in CSF of Alzheimer’s disease (AD) and frontotemporal lobar degeneration (FTLD) patients and is therefore considered a potential neuroinflammatory biomarker. Whether ch...

    Authors: Yanaika S. Hok-A-Hin, Jeroen J. M. Hoozemans, William T. Hu, Dorine Wouters, Jennifer C. Howell, Alberto Rábano, Wiesje M. van der Flier, Yolande A. L. Pijnenburg, Charlotte E. Teunissen and Marta del Campo
    Citation: Alzheimer's Research & Therapy 2022 14:100
  40. Decreased visual acuity (VA) is reported to be a risk factor for dementia. However, the association between VA and cortical thickness has not been established. We investigated the association between VA and co...

    Authors: Gyule Han, Ji Sun Kim, Yu Hyun Park, Sung Hoon Kang, Hang-Rai Kim, Song Hwangbo, Tae-Young Chung, Hee Young Shin, Duk L. Na, Sang Won Seo, Dong Hui Lim and Hee Jin Kim
    Citation: Alzheimer's Research & Therapy 2022 14:99
  41. People with subjective cognitive decline (SCD) report cognitive deterioration. However, their performance in neuropsychological evaluation falls within the normal range. The present study aims to analyse wheth...

    Authors: Pablo Arrondo, Óscar Elía-Zudaire, Gloria Martí-Andrés, María A. Fernández-Seara and Mario Riverol
    Citation: Alzheimer's Research & Therapy 2022 14:98
  42. The prevalence of dementia is expected to increase dramatically. Due to a lack of pharmacological treatment options for people with dementia, non-pharmacological treatments such as exercise programs have been ...

    Authors: Kathrin Steichele, Anne Keefer, Nikolas Dietzel, Elmar Graessel, Hans-Ulrich Prokosch and Peter L. Kolominsky-Rabas
    Citation: Alzheimer's Research & Therapy 2022 14:97
  43. Isolated subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are the prodromal phases of dementia with Lewy bodies (DLB). MEMENTO is a nationwide study of patients with SCI and MCI with c...

    Authors: Frederic Blanc, Vincent Bouteloup, Claire Paquet, Marie Chupin, Florence Pasquier, Audrey Gabelle, Mathieu Ceccaldi, Paulo Loureiro de Sousa, Pierre Krolak-Salmon, Renaud David, Clara Fischer, Jean-François Dartigues, David Wallon, Olivier Moreaud, Mathilde Sauvée, Catherine Belin…
    Citation: Alzheimer's Research & Therapy 2022 14:96
  44. We previously identified four Alzheimer’s disease (AD) subgroups with increasingly higher cerebrospinal fluid (CSF) levels of tau phosphorylated at threonine 181 (p-tau). These subgroups included individuals a...

    Authors: Kirsten E. J. Wesenhagen, Betty M. Tijms, Lynn Boonkamp, Patty L. Hoede, Julie Goossens, Nele Dewit, Philip Scheltens, Eugeen Vanmechelen, Pieter Jelle Visser and Charlotte E. Teunissen
    Citation: Alzheimer's Research & Therapy 2022 14:95
  45. Multidomain trials to prevent dementia by simultaneously targeting multiple risk factors with non-pharmacological lifestyle interventions show promise. Designing trials to evaluate the efficacy of individual i...

    Authors: Manuel Montero-Odasso, G Y Zou, Nellie Kamkar, Howard H. Feldman, Sylvie Belleville, Howard Chertkow, Haakon B Nygaard, Surim Son and Mark Speechley
    Citation: Alzheimer's Research & Therapy 2022 14:94
  46. About 40–50% of patients with amnestic mild cognitive impairment (MCI) are found to have no significant Alzheimer’s pathology based on amyloid PET positivity. Notably, conversion to dementia in this population...

    Authors: Hyung-Ji Kim, Jungsu S. Oh, Jae-Sung Lim, Sunju Lee, Sungyang Jo, E-Nae Chung, Woo-Hyun Shim, Minyoung Oh, Jae Seung Kim, Jee Hoon Roh and Jae-Hong Lee
    Citation: Alzheimer's Research & Therapy 2022 14:93
  47. Alzheimer’s disease (AD) pathology is associated with complex interactions among multiple factors, involving an intertwined network of various signaling pathways. The polypharmacological approach is an emergin...

    Authors: Byung Woo Kang, Fred Kim, Joon-Yong Cho, SangYun Kim, Jinseol Rhee and Jai Jun Choung
    Citation: Alzheimer's Research & Therapy 2022 14:92
  48. Safety concerns against the use of proton pump inhibitors (PPIs) based on the risk of dementia, especially Alzheimer’s disease (AD), remain controversial. Here, we investigated the likelihood of AD depending o...

    Authors: Hyo Geun Choi, Joo-Hee Kim, Ji Hee Kim, Eun Soo Kim, Ha Young Park, Kyueng-Whan Min and Mi Jung Kwon
    Citation: Alzheimer's Research & Therapy 2022 14:91
  49. To promote the development of effective therapies, there is an important need to characterize the full spectrum of neuropathological changes associated with Alzheimer’s disease. In line with this need, this st...

    Authors: Dorothee Schoemaker, Maria Clara Zanon Zotin, Kewei Chen, Kay C. Igwe, Clara Vila-Castelar, Jairo Martinez, Ana Baena, Joshua T. Fox-Fuller, Francisco Lopera, Eric M. Reiman, Adam M. Brickman and Yakeel T. Quiroz
    Citation: Alzheimer's Research & Therapy 2022 14:89
  50. The apolipoprotein E (APOE) ε4 allele confers the strongest risk for late-onset Alzheimer’s disease (AD) besides age itself, but the mechanisms underlying this risk are debated. One hypothesis supported by eviden...

    Authors: Noah R. Johnson, Athena C.-J. Wang, Christina Coughlan, Stefan Sillau, Esteban Lucero, Lisa Viltz, Neil Markham, Cody Allen, A. Ranjitha Dhanasekaran, Heidi J. Chial and Huntington Potter
    Citation: Alzheimer's Research & Therapy 2022 14:88