Fig. 3
Associations between polygenic risk scores for Alzheimer’s disease and volume of subcortical structures. A Barcharts of variance explained by AD PRS (R2, y-axis) constructed at each of eight p-value thresholds (x-axis) for a volume of 7 subcortical structures: accumbens, amygdala, thalamus, hippocampus, pallidum, caudate, and putamen. Red and blue colors respectively correspond to positive and negative associations. Asterisks indicate p-values after FDR correction: *FDR < 0.05, **FDR < 0.01, ***FDR < 0.001. B Subcortical t-maps representing t-values of association between AD PRS (at p-value threshold = 5e − 6) and volume of subcortical structures. Regions where the association with PRS is significant after FDR correction (FDR < 5%) are labeled by name. Abbreviations: ABCD, Adolescent Brain Cognitive Development Study; UKB, UK Biobank; PT, p-value thresholds; PRS, polygenic risk scores; SV, subcortical volume