Fig. 2

Associations between polygenic risk scores for Alzheimer’s disease and cortical macrostructural MRI metrics. A Heatmap of regional associations between CA, CT, CV, and all eight AD PRS. The rows represent the 34 cortical regions, and the columns represent the eight AD PRSs used in our study. Asterisks indicate p-values after FDR correction: *FDR < 0.05, **FDR < 0.01. B Cortical t-maps representing t-values of association between AD PRS (at p-value threshold = 5e − 6) and regional cortical MRI metrics. Regions where the association with PRS is significant after FDR correction (FDR < 5%) are labeled by name. Abbreviations: ABCD, Adolescent Brain Cognitive Development Study; UKB, UK Biobank; CT, cortical thickness; CV, cortical volume; CA, cortical area