From: Plasma and cerebrospinal fluid cholesterol esterification is hampered in Alzheimer’s disease
AD | CN | |
---|---|---|
N | 70 | 74 |
Sex (M/F) | 34/36 | 37/37 |
Age (y) | 73.6 ± 6.6 | 70.8 ± 9.8 |
MMSE (score) | 20.9 ± 4.2 | |
CDR (score) | 1.4 ± 0.7 | |
Disease biomarkersa | ||
Aβ1-42 (pg/mL) | 442 (303; 572) | 1,034 (608; 1,765) |
Aβ1-40 (pg/mL) | 10,482 (7838; 12,869) | n.a |
T-tau (pg/mL) | 673 (464; 965) | 176 (93; 325) |
P-tau (pg/mL) | 100 (78; 147) | 33 (24; 48) |
Aβ1-42/Aβ1-40 | 0.044 (0.038; 0.051) | n.a |
Aβ1-42/T-tau | 0.67 (0.36; 1.09) | 6.40 (2.01; 14.53) |
Aβ1-42/P-tau | 4.4 (2.5; 6.3) | 30.34 (13.78; 53.13) |
Apolipoprotein E genotype (N, %)b | ||
E4/E4 | 4 (5.8) | 2 (5.9) |
E3/E4 | 30 (43.5) | 4 (11.8) |
E3/E3 | 33 (47.8) | 25 (73.5) |
E2/E3 | 2 (2.9) | 3 (8.8) |
Statins (N, %) | 19 (27.1) | 5 (6.8) |