Plasma NfL is associated with the APOE ε4 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults

Table 2 Neuroimaging predictors of plasma NfL

Neuroimaging variable	Beta value	95% confidence interval	P-value	MSE
Relative hippocampal volume (n = 192)^a	− 0.12	(− 0.21, − 0.02)	0.02	0.13
Hypometabolic convergence index (n = 194)	0.01	(0.002, 0.03)	0.03*	0.12
White matter hyperintensity volume (n = 150)	0.002	(− 0.006, 0.01)	0.56	0.12
PiB SUVR (n = 110)	0.06	(− 0.31, 0.44)	0.75	0.17
Tau meta ROI (n = 56)	0.85	(− 0.02, 1.77)	0.07	0.12
Tau entorhinal SUVR (n = 56)	0.95	(0.23, 1.68)	0.01	0.10
Tau inferior temporal SUVR (n = 56)	0.66	(− 0.08, 1.41)	0.09	0.12
Entorhinal cortex thickness (n = 156)	− 0.10	(− 0.23, 0.02)	0.11	0.14
Inferior temporal thickness (n = 156)	− 0.10	(− 0.20, 0.007)	0.07	0.14
Parahippocampal thickness (n = 156)	− 0.25	(− 0.42, − 0.08)	0.005	0.13

All models adjusted for age, sex, education, and APOE ε4 genotype; for PiB SUVR, only 19% of subjects were amyloid positive (SUVR > = 1.47)
^aScaled to 1000X; MSE—mean squared error of regression model where values closer to zero indicate better fit. False discovery rate significance level was ɑ = 0.025
^*Not statistically significant after FDR adjustment

ISSN: 1758-9193