Table 1 Comparison between the Controls and the NDG groups on demographics, reference CNB, SCD-T and acceptability

Demographics

 Age, year sold

69.91 ± 4.86

72.61 ± 6.79

0.011*

 Gender (Female)

44 (67.69%)

29 (45.31%)

0.013*

 Educational level

   ≤ 12 years

9 (13.85%)

17 (26.56%)

0.204

  between 13 and 17 years

32 (49.23%)

26 (40.62%)

   ≥ 17 years

24 (36.92%)

21 (32.81%)

 Delay between SCD-T and reference CN-Battery, months

-0.44 ± 0.80

1.12 ± 1.36

 < 0.001*

Medical history

 cardiovascular diseases^¥

5 (7.69%)

10 (15.62%)

OR: 0.72 ± 0.47

0.615

 hypertension^¥

15 (23.08%)

25 (39.06%)

OR: 0.51 ± 0.22

0.161

 diabetes^¥

2 (3.08%)

8 (12.50%)

OR: 0.38 ± 0.32

0.262

 depression^¥

5 (7.69%)

17 (26.56%)

OR: 0.16 ± 0.09

0.001*

Reference CNB

 HAD

8.65 ± 4.50

12.14 ± 6.60

MD: -4.57 ± 1.08

 < 0.001*

 MMSE^#

28.95 ± 0.89

24.94 ± 2.40

MD: 1.74 ± 0.14

 < 0.001*

 FAB^#

17.31 ± 0.97

14.38 ± 2.43

MD: 1.79 ± 0.18

 < 0.001*

 FCSRT free recall^#

34.72 ± 5.19

10.39 ± 7.97

MD: 2.23 ± 0.06

 < 0.001*

 FCSRT total recall^#

47.02 ± 1.29

25.25 ± 14.07

MD: 3.94 ± 0.14

 < 0.001*

 TMT A time, seconds

61.08 ± 42.88

 TMT B time, seconds

145.71 ± 80.16

 TMT B-A, time, seconds

98.24 ± 73.06

SCD-T

 Time to complete SCD-T (minutes)

21.67 ± 4.77

40.74 ± 12.06

MD: -18.35 ± 1.67

 < 0.001*

 MacNair

12.42 ± 6.53

17.78 ± 7.26

MD: -6.81 ± 1.26

 < 0.001*

 GDS

2.05 ± 1.99

3.17 ± 3.19

MD: -1.48 ± 0.49

0.003*

 NCT good answers

32.88 ± 7.55

14.75 ± 8.71

MD: 16.86 ± 1.47

 < 0.001*

 NCT wrong answers

1.65 ± 1.89

3.48 ± 4.62

MD: -1.08 ± 0.63

0.186

 NCT total answers

34.52 ± 6.79

18.23 ± 8.46

MD: 15.78 ± 1.36

 < 0.001*

 5-WT total score^#

9.74 ± 0.54

6.31 ± 2.34

MD: 3.11 ± 0.27

 < 0.001*

 5-WT weighted total score^#

18.88 ± 1.55

10.88 ± 3.99

MD: 2.63 ± 0.14

 < 0.001*

 TMT A time, seconds

26.62 ± 13.13

45.61 ± 34.33

MD: -17.63 ± 4.92

 < 0.001*

 TMT B time, seconds

52.37 ± 23.14

125.42 ± 87.38

MD: -74.48 ± 12.01

 < 0.001*

 TMT B-A, time, seconds

25.85 ± 23.21

79.83 ± 76.00

MD: -56.77 ± 10.51

 < 0.001*

Acceptability

 SUS

92.23 ± 10.75

79.49 ± 18.70

MD: 11.39 ± 2.80

 < 0.001*

 QCT: successful as person of the same age¹(≥ Good)^¥

40 (61.54%)

11 (17.19%)

OR: 8.26 ± 3.84

 < 0.001*

 QCT: representative memory/attention²(≥ fairly representative)^¥

55 (84.62%)

47 (73.44%)

OR: 1.51 ± 0.73

0.395

 QCT: perception³(≥ Good)^¥

49 (75.38%)

31 (48.44%)

OR: 5.23 ± 2.33

 < 0.001*

 QCT: clear instructions⁴(≥ fairly clear)

64 (98.46%)

60 (93.75%)

ND

ND

 QCT: requires no explanation by a third party^{5 ¥}

60 (92.31%)

46 (71.88%)

OR: 4.57 ± 2.61

0.005*