Table 7 Linear mixed model results of the MCI and dementia groups stratified by APOE ε4 status
MCI group | Dementia group | |||||||
|---|---|---|---|---|---|---|---|---|
APOEε4 positive (n = 58) | APOEε4 negative (n = 48) | APOEε4 positive (n = 36) | APOEε4 negative (n = 14) | |||||
Effect | Slope (95% CI) | p-value | Slope (95% CI) | p-value | Slope (95% CI) | p-value | Slope (95% CI) | p-value |
MMSE | ||||||||
CSF ApoA1 | − 0.059 (0.302, 0.183) | 0.63 | 0.233 (− 0.024, 0.489) | 0.075 | − 1.029 (− 1.950, − 0.108) | 0.029 | 1.078 (− 0.205, 2.361) | 0.097 |
Plasma ApoA1 | − 0.798 (− 1.258, − 0.339) | < 0.001 | − 0.474 (− 0.740, − 0.209) | < 0.001 | − 1.715 (− 3.285, − 0.146) | 0.033 | − 0.794 (− 3.923, 2.336) | 0.61 |
Plasma TG/HDL | − 0.327 (− 0.562, − 0.093) | 0.006 | − 0.044 (− 0.173, 0.084) | 0.50 | − 0.559 (− 1.279, 0.162) | 0.13 | 0.960 (− 1.045, 2.965) | 0.34 |
CDR-SB | ||||||||
CSF ApoA1 | 0.220 (0.057, 0.383) | 0.008 | 0.076 (− 0.113, 0.264) | 0.43 | 0.137 (− 0.451, 0.725) | 0.64 | − 0.474 (− 1.245, 0.297) | 0.22 |
Plasma ApoA1 | 0.518 (0.199, 0.838) | 0.002 | − 0.032 (− 0.229, 0.164) | 0.75 | 0.656 (− 0.346, 1.658) | 0.19 | 0.729 (− 1.151, 2.609) | 0.44 |
TG/HDL | 0.287 (0.126, 0.448) | < 0.001 | 0.057 (− 0.038, 0.152) | 0.24 | 0.580 (0.120, 1.040) | 0.014 | − 0.112 (− 1.316, 1.093) | 0.85 |
LM | ||||||||
CSF ApoA1 | 0.017 (− 0.156, 0.190) | 0.84 | 0.093 (− 0.163, 0.350) | 0.47 | 0.042 (− 0.282, 0.366) | 0.79 | 0.613 (− 0.008, 1.234) | 0.053 |
Plasma ApoA1 | 0.220 (− 0.108, 0.549) | 0.19 | − 0.598 (− 0.866, − 0.330) | < 0.001 | 0.068 (− 0.479, 0.615) | 0.80 | − 2.753 (− 4.268, − 1.239) | < 0.001 |
Plasma TG/HDL | 0.125 (− 0.044, 0.293) | 0.15 | 0.002 (− 0.127, 0.130) | 0.98 | 0.142 (− 0.117, 0.402) | 0.28 | − 0.548 (− 1.518, 0.423) | 0.26 |