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Table 5 Correlations between lipid variables and CSF and plasma BBB integrity biomarkers in the dementia group

From: Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease

  

All dementia

Apoe4 ε + 

Apoe4ε-

Factor 1

Factor 2

N

rho (95% CI)

p-value

N

rho (95% CI)

p-value

N

rho (95% CI)

p-value

CSF ApoA1

CSF ICAM1

50

0.55 (0.32, 0.72)

 < 0.001

36

0.64 (0.40, 0.80)

 < 0.001

14

0.39 (− 0.18, 0.76)

0.18

CSF VCAM1

50

0.62 (0.41, 0.77)

 < 0.001

36

0.64 (0.40, 0.80)

 < 0.001

14

0.57 (0.06, 0.85)

0.030

Plasma ICAM1

50

0.04 (− 0.24, 0.31)

0.79

36

0.18 (− 0.16, 0.48)

0.29

14

 − 0.31 (− 0.72, 0.27)

0.30

Plasma MMP9

50

0.07 (− 0.22, 0.34)

0.65

36

 − 0.02 (− 0.35, 0.31)

0.90

14

0.29 (− 0.29, 0.71)

0.33

Plasma VCAM1

50

0.07 (− 0.21, 0.34)

0.63

36

0.06 (− 0.27, 0.38)

0.73

14

0.09 (− 0.46, 0.59)

0.76

Plasma ApoA1

CSF ICAM1

50

 − 0.02 (− 0.29, 0.26)

0.90

36

 − 0.02 (− 0.34, 0.31)

0.93

14

 − 0.02 (− 0.55, 0.52)

0.94

CSF VCAM1

50

 − 0.02 (− 0.30, 0.26)

0.89

36

0.02 (− 0.31, 0.35)

0.89

14

 − 0.19 (− 0.65, 0.38)

0.52

Plasma ICAM1

50

 − 0.15 (− 0.41, 0.14)

0.31

36

 − 0.14 (− 0.45, 0.20)

0.41

14

 − 0.19 (− 0.65, 0.38)

0.52

Plasma MMP9

50

0.14 (− 0.15, 0.40)

0.34

36

0.14 (− 0.20, 0.45)

0.42

14

0.11 (− 0.44, 0.61)

0.70

Plasma VCAM1

50

0.07 (− 0.21, 0.34)

0.63

36

0.15 (− 0.19, 0.46)

0.38

14

 − 0.20 (− 0.66, 0.37)

0.50

TG/HDL

CSF ICAM1

50

 − 0.00 (− 0.28, 0.28)

0.98

36

 − 0.07 (− 0.39, 0.26)

0.67

14

0.11 (− 0.45, 0.61)

0.71

CSF VCAM1

50

 − 0.09 (− 0.36, 0.19)

0.51

36

 − 0.17 (− 0.47, 0.17)

0.33

14

0.06 (− 0.49, 0.57)

0.85

Plasma ICAM1

50

0.30 (0.02, 0.53)

0.036

36

0.28 (− 0.05, 0.56)

0.097

14

0.34 (− 0.23, 0.74)

0.24

Plasma MMP9

50

 − 0.20 (− 0.45, 0.09)

0.18

36

 − 0.10 (− 0.41, 0.24)

0.57

14

 − 0.43 (− 0.78, 0.13)

0.13

Plasma VCAM1

50

0.01 (− 0.27, 0.29)

0.95

36

 − 0.13 (− 0.44, 0.20)

0.44

14

0.39 (− 0.18, 0.76)

0.17

  1. rho, Pearson’s correlation; CI, confidence interval; FDR < 0.05 in bold; ApoA1, apolipoprotein; TG/HDL, plasma triglyceride/HDL cholesterol ratio