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Table 4 Correlations between lipid variables and CSF and plasma BBB integrity biomarkers in the MCI group

From: Metabolic syndrome biomarkers relate to rate of cognitive decline in MCI and dementia stages of Alzheimer’s disease

  

All MCI

Apoeε4 + 

Apoe4ε -

Factor 1

Factor 2

N

rho (95% CI)

p-value

N

rho (95% CI)

p-value

N

rho (95% CI)

p-value

CSF ApoA1

CSF ICAM1

106

0.54 (0.39, 0.66)

 < 0.001

58

0.51 (0.29, 0.68)

 < 0.001

48

0.59 (0.37, 0.75)

 < 0.001

CSF VCAM1

106

0.42 (0.25, 0.57)

 < 0.001

58

0.31 (0.06, 0.53)

0.017

48

0.50 (0.25, 0.69)

 < 0.001

Plasma ICAM1

106

0.04 (− 0.15, 0.23)

0.69

58

0.03 (− 0.23, 0.29)

0.81

48

 − 0.00 (− 0.29, 0.28)

0.99

Plasma MMP9

106

 − 0.09 (− 0.27, 0.10)

0.37

58

 − 0.11 (− 0.36, 0.16)

0.43

48

 − 0.05 (− 0.33, 0.23)

0.72

Plasma VCAM1

106

0.07 (− 0.13, 0.25)

0.50

58

0.15 (− 0.12, 0.39)

0.27

48

 − 0.07 (− 0.35, 0.22)

0.62

Plasma ApoA1

CSF ICAM1

106

 − 0.20 (− 0.37, − 0.01)

0.044

58

 − 0.18 (− 0.42, 0.08)

0.18

48

 − 0.22 (− 0.47, 0.07)

0.13

CSF VCAM1

106

 − 0.32 (− 0.48, − 0.13)

 < 0.001

58

 − 0.44 (− 0.62, − 0.20)

 < 0.001

48

 − 0.18 (− 0.44, 0.11)

0.22

Plasma ICAM1

106

0.04 (− 0.16, 0.22)

0.72

58

0.21 (− 0.05, 0.44)

0.12

48

 − 0.11 (− 0.38, 0.18)

0.48

Plasma MMP9

106

 − 0.02 (− 0.21, 0.17)

0.86

58

 − 0.16 (− 0.40, 0.10)

0.22

48

0.15 (− 0.14, 0.42)

0.30

Plasma VCAM1

106

 − 0.15 (− 0.33, 0.05)

0.13

58

 − 0.07 (− 0.33, 0.19)

0.58

48

 − 0.16 (− 0.42, 0.13)

0.28

TG/HDL

CSF ICAM1

106

0.09 (− 0.11, 0.27)

0.38

58

 − 0.06 (− 0.31, 0.20)

0.68

48

0.25 (− 0.04, 0.50)

0.092

CSF VCAM1

106

0.32 (0.14, 0.48)

 < 0.001

58

0.34 (0.09, 0.55)

0.009

48

0.30 (0.02, 0.54)

0.038

Plasma ICAM1

106

0.01 (− 0.18, 0.20)

0.92

58

 − 0.14 (− 0.39, 0.12)

0.29

48

0.19 (− 0.10, 0.45)

0.20

Plasma MMP9

106

0.13 (− 0.06, 0.31)

0.19

58

0.21 (− 0.05, 0.44)

0.11

48

0.02 (− 0.27, 0.30)

0.90

Plasma VCAM1

106

0.12 (− 0.07, 0.31)

0.21

58

 − 0.12 (− 0.36, 0.15)

0.39

48

0.36 (0.08, 0.58)

0.012

  1. rho Pearson’s correlation, CI Confidence interval, FDR < 0.05 in bold, ApoA1 Apolipoprotein, TG/HDL Plasma triglyceride/HDL cholesterol ratio