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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Attenuation of Alzheimer’s brain pathology in 5XFAD mice by PTH1-34, a peptide of parathyroid hormone

Fig. 2

PTH1-34 attenuation of cognition decline and memory loss in 5XFAD female mice. A Illustration of PTH1-34 or vehicle intermittent treatment in WT/5XFAD female mice and behavioral testing schedule. All mice were tested for behavior from the age of 5 ~ MO old and treated with PTH1-34/Veh continuously during the testing procedure. The results shown in this figure were for female mice. B, C Novel object recognition (NOR): Representative tracing images (B), and the quantification of discrimination index ([novel object explore time − old object explore time]/[total explore time]) of NOR (C) were shown. D Y maze: Quantifications of the total arm entries and spontaneous alternation. EH Morris water maze (MWM): The latencies to reach the hidden platform during the training period (E), the representative tracing images (F), quantification of time spent in the target quadrant (G), and target zone crossovers (H) on the testing day were showed. All quantification data were presented as mean ± SD (n = 6–8 female mice per group). *P < 0.05, **P < 0.01, two-way ANOVA with two-stage step-up method of Benjamini, Krieger, and Yekutieli multiple comparisons test was used

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