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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Changes in CSF sPDGFRβ level and their association with blood–brain barrier breakdown in Alzheimer’s disease with or without small cerebrovascular lesions

Fig. 2

Mediation analysis regarding the proportion to which CSF sPDGFRβ alteration affects the process of BBB damage. Mediation analysis included the following variables: the concentration of CSF sPDGFRβ was treated as a mediator, Q-alb was set as the dependent variable, and Aβ42/Aβ40 ratio was set as the independent variable. Analyses based on multiple linear regression models with sex, age, and APOE genotype was adjusted as covariates. The values for CSF sPDGFRβ levels and the Q-alb ratio were ln-transformed. A value of p < 0.05 was considered statistically significant

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