Fig. 3

CSF and serum Aβ42/Aβ40 ratios and their associations with cerebral Aβ plaque burden in App^{NL−F/NL−F} knock-in mice. In the whole study population, the Aβ42/Aβ40 ratio in CSF and serum inversely correlated with A–D Aβ42 immunoreactivity and E–H thioflavin S-positive fibrillar dense-core plaques in the cortex and hippocampus. Correlation analyses were performed using Spearman’s rank-ordered correlation coefficient. Abbreviations: Aβ, amyloid beta; CSF, cerebrospinal fluid