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Fig. 9 | Alzheimer's Research & Therapy

Fig. 9

From: Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse

Fig. 9

Phosphorylation levels of NF-κB and IRF3 in mouse brains. A, B Representative Western blot images for NF-κB and IRF3 in the cortex of each mouse. C In the cortex, the p-NF-κB level was significantly increased in AD + Saline mice and AD + Poly(I:C) mice compared with that in WT + Saline mice (P < 0.05). No significant difference was found between AD + Saline mice and AD + Poly(I:C) mice (P > 0.05). E, F Representative Western blot images for NF-κB and IRF3 in the hippocampus of each mouse. G Compared with that of WT + Saline mice, the p-NF-κB level was significantly upregulated in AD + Saline mice (P < 0.05) and significantly decreased in AD + Poly(I:C) mice compared with AD + Saline mice. D, H No significant difference was found in the phosphorylation level of IRF3 among the four groups in the cortical and hippocampal regions (P > 0.05) (#: WT + Saline vs. AD + Saline, P < 0.05; &: WT + Saline vs. AD + Poly(I:C), P < 0.05; *: AD + Saline vs. AD + Poly(I:C), P < 0.05; n = 4/group)

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