Fig. 8

Transcription level of cytokines in mouse brains. A, B In the cortex, the IL-1β and TNF-α levels in AD + Saline mice and AD + Poly(I:C) mice were significantly increased compared with those in WT + Saline mice (P < 0.05). No differences were observed between AD + Saline mice and AD + Poly(I:C) mice (P > 0.05). C In the cortex, the IL-4 level in AD + Saline mice was dramatically decreased in AD + Saline mice and AD + Poly(I:C) mice compared with that in WT + Saline mice (P < 0.05). No statistically significant difference was found between AD + Saline mice and AD + Poly(I:C) mice (P > 0.05). E, F In the hippocampus, the IL-1β and TNF-α levels in AD + Saline mice were significantly increased compared with those in WT + Saline mice (P < 0.05) and dramatically decreased in AD + Poly(I:C) mice compared with those in AD + Saline mice (P < 0.05). G In the hippocampus, the IL-4 level in AD + Saline mice was dramatically decreased in AD + Saline mice compared with that in WT + Saline mice (P < 0.05) and was significantly upregulated in AD + Poly(I:C) mice compared with that in AD + Saline mice (P < 0.05). D, H No significant difference was found in the IFN-β levels among the four groups in the cortical and hippocampal regions (P > 0.05) (#: WT + Saline vs. AD + Saline, P < 0.05; &: WT + Saline vs. AD + Poly(I:C), P < 0.05; *: AD + Saline vs. AD + Poly(I:C), P < 0.05; n = 4/group)