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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Early activation of Toll-like receptor-3 reduces the pathological progression of Alzheimer’s disease in APP/PS1 mouse

Fig. 6

Activation of astrocytes in mouse brains. A, B Representative immunofluorescence images of GFAP staining in the cortex and hippocampus. C, E Representative images of GFAP detected by Western blot in the cortex and hippocampus. D The GFAP levels were significantly higher in AD + Saline mice and AD + Poly(I:C) mice in the cortex than in the WT + Saline mice. F In the hippocampus, compared with the WT + Saline mice, GFAP levels were significantly higher in AD + Saline mice and AD + Poly(I:C) mice and lower in AD + Poly(I:C) mice than in AD + Saline mice (#: WT + Saline vs. AD + Saline, P < 0.05; &: WT + Saline vs. AD + Poly(I:C), P < 0.05; *: AD + Saline vs. AD + Poly(I:C), P < 0.05; n = 4/group)

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