Exploring the ATN classification system using brain morphology

Table 2 Assessment of face validity of the ACH in selected ROIs

Region	Sequence with highest evidence	T	P	ACH on rank nr. (of 24)	ACH VX%
AMG	ACH	−13.69	2.53e−34	1	80.99
Hippocampus	AP 1	−14.88	6.76e−39	5	26.27
Entorhinal cortex	ACH	−7.30	1.13e−12	1	48.46
Precuneus	AP 2	−3.90	5.76e−05	4	13.78
Braak I/II	ACH	−16.11	1.15e−43	1	25.13
Braak III/IV	Other1	−6.97	8.59e−12	5	17.97
Braak V/VI	Other1	5.06	3.54e−07	5	7.31

ROI-based comparison of evidence for a monotonic volume decline over 24 sequences obtained by permutation of the ACH progression sequence. Braak stage volumes were obtained using aggregated Freesurfer ROI volumes. ACH: A−T−N−➔A+T−N−➔A+T+N−➔A+T+N+; AP 1: A+T−N−➔A+T+N−➔A−T−N−➔A+T+N+; AP 2: A+T−N−➔A−T−N−➔A+T+N−➔A+T+N+; Other1: A+T+N− ➔ A+T−N− ➔ A−T−N− ➔ A+T+N+. ACH VX%: Percentage of voxels with highest evidence for ACH sequence inside the ROI mask

ISSN: 1758-9193