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Table 1 DELCODE sample characteristics and ATN group classification

From: Exploring the ATN classification system using brain morphology

ATN groups

Normal

Non-AD pathologic change

Alzheimer’s continuum groups

A−T−N−

A−T−N+

A−T+N−

A−T+N+

A+T−N−

A+T−N+

A+T+N−

A+T+N+

Group size

143

41

29

14

45

23

61

81

Age (years) mean (SD)

69.64 (5.50)

68.10 (5.85)

70.20 (4.56)

70.86 (5.90)

69.97 (5.12)

70.91 (7.10)

73.20 (5.30)

73.46 (5.84)

Sex (% female)

48.25%

48.78%

72.41%

28.57%

42.22%

39.13%

47.54%

55.56%

Education years mean (SD)

14.65 (2.92)

14.71 (2.87)

13.79 (2.02)

16.57 (2.53)

14.07 (2.53)

14.43 (3.19)

13.67 (3.33)

13.75 (2.98)

MMSE mean (SD)

29.15 (1.19)

28.54 (1.98)

29.14 (1.27)

29.14 (1.61)

29.24 (0.77)

27.52 (3.29)

27.52 (3.06)

26.12 (3.23)

Memory performance mean (SD)

0.39 (0.51)

0.13 (0.84)

0.42 (0.67)

0.01 (0.99)

0.35 (0.64)

−0.52 (1.05)

−0.44 (1.09)

−1.18 (1.00)

CSF Aβ42/40 mean (SD)

0.110 (0.011)

0.108 (0.011)

0.112 (0.013)

0.118 (0.014)

0.074 (0.012)

0.064 (0.015)

0.053 (0.011)

0.050 (0.013)

CSF phospho-tau (pg/ml) mean (SD)

41.02 (8.81)

39.85 (11.84)

68.02 (10.88)

74.68 (19.41)

41.88 (9.99)

44.49 (9.40)

93.26 (50.38)

95.06 (31.09)

CSF total tau (pg/ml) mean (SD)

288.18 (89.16)

291.24 (131.09)

465.98 (115.59)

544.38 (167.71)

321.41 (104.50)

312.96 (94.48)

677.41 (335.83)

778.43 (287.03)

aHV (ml) mean (SD)

3.14 (0.21)

2.64 (0.15)

3.18 (0.24)

2.63 (0.11)

3.12 (0.21)

2.60 (0.21)

3.12 (0.23)

2.56 (0.22)

WMH (ml) mean (SD)

3.29 (5.31)

3.27 (6.07)

1.42 (1.70)

2.09 (2.83)

3.19 (3.61)

4.66 (6.05)

6.99 (11.61)

6.34 (7.96)

  1. Overview of descriptive characteristics of the DELCODE sample and ATN group statistics. Non-AD pathologic change ATN groups that are related to neuronal conditions other than AD, Alzheimer’s continuum groups Aβ-positive groups that are related to AD
  2. aHV adjusted hippocampal volume, WMH white matter hyperintensities