From: Exploring the ATN classification system using brain morphology
ATN groups | Normal | Non-AD pathologic change | Alzheimer’s continuum groups | |||||
---|---|---|---|---|---|---|---|---|
A−T−N− | A−T−N+ | A−T+N− | A−T+N+ | A+T−N− | A+T−N+ | A+T+N− | A+T+N+ | |
Group size | 143 | 41 | 29 | 14 | 45 | 23 | 61 | 81 |
Age (years) mean (SD) | 69.64 (5.50) | 68.10 (5.85) | 70.20 (4.56) | 70.86 (5.90) | 69.97 (5.12) | 70.91 (7.10) | 73.20 (5.30) | 73.46 (5.84) |
Sex (% female) | 48.25% | 48.78% | 72.41% | 28.57% | 42.22% | 39.13% | 47.54% | 55.56% |
Education years mean (SD) | 14.65 (2.92) | 14.71 (2.87) | 13.79 (2.02) | 16.57 (2.53) | 14.07 (2.53) | 14.43 (3.19) | 13.67 (3.33) | 13.75 (2.98) |
MMSE mean (SD) | 29.15 (1.19) | 28.54 (1.98) | 29.14 (1.27) | 29.14 (1.61) | 29.24 (0.77) | 27.52 (3.29) | 27.52 (3.06) | 26.12 (3.23) |
Memory performance mean (SD) | 0.39 (0.51) | 0.13 (0.84) | 0.42 (0.67) | 0.01 (0.99) | 0.35 (0.64) | −0.52 (1.05) | −0.44 (1.09) | −1.18 (1.00) |
CSF Aβ42/40 mean (SD) | 0.110 (0.011) | 0.108 (0.011) | 0.112 (0.013) | 0.118 (0.014) | 0.074 (0.012) | 0.064 (0.015) | 0.053 (0.011) | 0.050 (0.013) |
CSF phospho-tau (pg/ml) mean (SD) | 41.02 (8.81) | 39.85 (11.84) | 68.02 (10.88) | 74.68 (19.41) | 41.88 (9.99) | 44.49 (9.40) | 93.26 (50.38) | 95.06 (31.09) |
CSF total tau (pg/ml) mean (SD) | 288.18 (89.16) | 291.24 (131.09) | 465.98 (115.59) | 544.38 (167.71) | 321.41 (104.50) | 312.96 (94.48) | 677.41 (335.83) | 778.43 (287.03) |
aHV (ml) mean (SD) | 3.14 (0.21) | 2.64 (0.15) | 3.18 (0.24) | 2.63 (0.11) | 3.12 (0.21) | 2.60 (0.21) | 3.12 (0.23) | 2.56 (0.22) |
WMH (ml) mean (SD) | 3.29 (5.31) | 3.27 (6.07) | 1.42 (1.70) | 2.09 (2.83) | 3.19 (3.61) | 4.66 (6.05) | 6.99 (11.61) | 6.34 (7.96) |