Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer’s disease

Table 3 Covariates selected for the APCC models

	Progressors		Non/late progressors
	Impacting baseline values^a	Impacting the progression rate	Impacting baseline values^a	Impacting the progression rate
APCC at baseline	X	X	X	X
APOE4 status		X		X
Years of education	X	X	X	X
Age at baseline			X	X
Age at the time of event	X

APCC Alzheimer’s Prevention Initiative Preclinical Composite Cognitive, APOE4 apolipoprotein E ε4
^aCovariates impacting the individual’s APCC value 12 years before the first diagnosis. Baseline covariates centered around observed medians: APCC logit-transformed and centered around the value 62, age around 74, and years of education around 16. APOE4 status includes homozygotes, heterozygotes, and non-carriers/non-genotyped

ISSN: 1758-9193