Table 2 Baseline characteristics and outcomes of initially cognitively unimpaired individuals
ROS/MAP/MARS, N = 1682 | NACC, N = 8218 | ADNI, N = 490 | |
|---|---|---|---|
Sex, n (%) | |||
Female | 1272 (75.6%) | 5326 (64.8%) | 253 (51.6%) |
APOE4 status, n (%) | |||
Homozygote | 29 (1.7%) | 147 (1.8%) | 11 (2.2%) |
Heterozygote | 285 (16.9%) | 1747 (21.3%) | 131 (26.7%) |
Non-carrier | 1033 (61.4%) | 4634 (56.4%) | 348 (71.0%) |
Unknown/not genotyped | 335 (19.9%) | 1690 (20.6%) | Not included |
Progressed during the observation period, n (%) | |||
To MCI | 462 (27.5%) | 1307 (15.9%) | 80 (16.3%) |
To dementia due to AD | 290 (17.2%) | 569 (6.9%) | 25 (5.1%) |
To MCI or dementia due to AD | 497 (29.6%) | 1579 (19.2%) | 80 (16.3%) |
Progressed within 8 years, n (%) | |||
To MCI | 360 (21.4%) | 1305 (15.9%) | 71 (14.5%) |
To dementia due to AD | 170 (10.1%) | 568 (6.8%) | 14 (2.9%) |
To MCI or dementia due to AD | 389 (23.1%) | 1577 (19.2%) | 73 (14.9%) |
Age at study entry in years | |||
Mean (SD) | 76.2 (7.4) | 73.9 (8.2) | 74.3 (5.8) |
Age category, n (%) | |||
Below 60 | Not included | Not included | 4 (0.8%) |
60 to < 65 | 56 (3.3%) | 1116 (13.6%) | 10 (2.0%) |
65 to < 70 | 359 (21.3%) | 1593 (19.4%) | 91 (18.6%) |
70 to < 75 | 358 (21.3%) | 1776 (21.6%) | 168 (34.3%) |
75 years of age or older | 909 (54.0%) | 3733 (45.4%) | 217 (44.3%) |
Years of education | |||
Median (interquartile range) | 16 (13–18) | 16 (13–18) | 16 (14–18) |
Follow-up in years | |||
Median (interquartile range) | 6 (3–10) | 4 (2–6) | 3.5 (2–5) |