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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Rationale for the selection of dual primary endpoints in prevention studies of cognitively unimpaired individuals at genetic risk for developing symptoms of Alzheimer’s disease

Fig. 1

Cognitive composites over time by progressor status: Individual time profiles and LOESS estimates. APCC, Alzheimer’s Prevention Initiative Preclinical Composite Cognitive; LOESS, locally estimated scatterplot smoothing; MCI, mild cognitive impairment; NACC, National Alzheimer’s Coordinating Center; PACC, Preclinical Alzheimer Cognitive Composite; RBANS, Repeatable Battery for the Assessment of Neuropsychological Status; ROS/MAP/MARS, Religious Orders Study/Memory and Aging Project/Minority Aging Research Study. Trajectories are anchored at the time of diagnosis for progressors to dementia and aligned by the median age of progressors at the time of diagnosis of dementia for progressors to MCI and for non-progressors to MCI/dementia

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Alzheimer's Research & Therapy

ISSN: 1758-9193