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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b

Fig. 2

In the current study, (1) rat cortical neurons (RCNs) were used as the cellular basis for investigation and (2) were either seeded with hAD tau or left as unseeded unseeded. Cells were (3) treated with 8 μm Anle138b for three different durations then (4) RNA-Seq experiments were undertaken to measure mRNA abundance. Once data was available, (5) chem- (ligand-target prediction) and bioinformatics analyses (pathway enrichment and causal reasoning) were carried out in parallel, and (6) integrated to generate hypotheses for the mechanism of action of Anle138b. Created with BioRender

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Alzheimer's Research & Therapy

ISSN: 1758-9193