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Table 1 Influx and efflux time constants of the CTL clusters. p-values of the two-sample t-test performed on the time constants τin and τout (reported as mean ± sem [min] across animals) representing the influx and efflux of DOTAREM for the CTL-based clusters. *p < 0.05

From: Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis

Cluster

CTL1

CTL2

CTL3

CTL4

CTL5

CTL6

p-value (in) = 

0.0149*

0.0248*

0.0199*

0.0274*

0.1893

0.6197

Ï„in (CTL) [min]

2.6 ± 1.5

3.9 ± 1.8

2.5 ± 1.7

2.0 ± 1.2

0.7 ± 0.1

0.8 ± 0.1

Ï„in (AD) [min]

13.1 ± 2.8

23.3 ± 6.8

22.6 ± 7.2

13.9 ± 3.9

9.9 ± 6.5

0.9 ± 0.1

p-value (out) = 

0.9047

0.2088

0.4702

0.9026

0.0955

0.6765

Ï„out (CTL) [min]

61.2 ± 25.1

46.0 ± 5.9

55.4 ± 8.3

65.1 ± 13.1

61.7 ± 9.0

34.2 ± 2.4

Ï„out (AD) [min]

58.0 ± 5.0

54.4 ± 1.8

56.5 ± 3.3

81.5 ± 17.4

116.7 ± 27.7

38.6 ± 9.9