Fig. 2
From: Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Spatial distribution maps of Gd-DOTA in the AD and CTL mice over time. A Schematic representation of the sagittal plane (interaural lateral − 0.04 mm) and transverse plane (Bregma level − 2.36 mm) from the Paxinos atlas with highlighted key regions such as olfactory bulb (OB), cerebellum (CB), hippocampus (HC), pons, medulla and ventricular system. B 3D visualisation of major blood vessels based on a recent vascular brain mouse atlas that was aligned to the template of this study (vascular atlas from [46]). The depicted vessels including OlfA (olfactory artery), Rrhv (rostral rhinal vein), Gcv (cerebral vein of Galen), Sss (superior sagittal sinus) and Trs (transverse sinus) are located in the vicinity of regions with enhanced contrast. C The spatial distribution of the MRI contrast agent in the CTL (top panel) and AD mice (bottom panel) at 30 min, 60 min, 90 min and 120 min post-intracisternal infusion shown in sagittal and transverse views. The colour scale represents the average percent signal intensity change, with dark blue/red indicating low/high percent signal intensity change, respectively