Fig. 1
From: Altered dynamics of glymphatic flow in a mature-onset Tet-off APP mouse model of amyloidosis
Overview of the experimental setup. The 14-month-old animals, AD and CTL, underwent the surgery after 11 months of amyloid-beta expression. The surgery started a few minutes after the anaesthesia induction (time point =  − 15 min) and the start of continuous Gd-DOTA infusion (2.5 µl, 0.55 µl/min) into the cisterna magna refers to the time point t = 0. The DCE-MRI acquisition (120 min) started 30 min post-Gd-DOTA injection, every 5 min, up to 150 min post-injection