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Table 2 Characteristics of the tau-PET patterns (discrete scale)

From: Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity

Subtypes at baseline (N=173)

TAD (N=57)

LP (N=21)

CP (N=31)

MT (N=64)

AD dementia/ prodromal AD/ cognitively normal (%)

28/42/30

24/24/52

6/32/61

2/17/80

Typicality (mean (SD))

1.3 (0.3) a, b, c

1.6 (0.3) a, b

0.9 (0.2) a

1.1 (0.2)

Severity (mean (SD))

1.9 (0.5) a, b, c

1.5 (0.1) a, b

1.6 (0.2) a

1.3 (0.1)

Age at baseline (years)

76.3 ± 7.3

[62, 90]

76.3 ± 6.4

[65, 90]

76.6 ± 7.8

[56, 91]

74.9 ± 7.8

[59, 92]

Sex (% female)

64.9

42.9

54.8

46.9

Education (years)

15.9 ± 2.3

[12, 20] a

15.6 ± 2.6

[12, 20] a

16.1 ± 2.4

[12, 20]

17 ± 2.4

[12, 20]

APOE ε4 carriers (%)

66.7

57.1

58.1

50.8

Retrospective MMSE

27.10 ± 3.15 [17, 30] a

27.25 ± 1.75 [24, 29] a

27.74 ± 2.40

[23, 30] a

29 ± 1.25

[26, 30]

Baseline MMSE

26.1 ± 4.3

[9, 30] a

26.8 ± 3.1

[20, 30] a, b

28.2 ± 2.1

[21, 30]

28.6 ± 1.9

[17, 30]

Prospective MMSE

25.6 ± 3.90

[13, 30] a, b

26.5 ± 4.22

[16, 30] a

28.37 ± 2.09 [21, 30]

28.81 ± 2.26

[17, 30]

Retrospective ADNI-MEM

0.33 ± 1.16

[−2.31, 2.08] a

0.31 ± 0.61

[−0.55, 1.51] a

0.73 ± 0.7

[−0.56, 1.95] a

1.19 ± 0.66

[−0.04, 2.57]

Baseline ADNI-MEM

0.10 ± 0.96

[−2.38, 2.01] a, b

0.19 ± 0.62

[−1.19, 1.21] a

0.55 ± 0.66

[−0.84, 1.69] a

0.93 ± 0.56

[−0.40, 2.10]

Prospective ADNI-MEM

−0.03 ± 1.08

[−2.56, 2.08] a, b

0.10 ± 0.82

[−1.39, 1.45] a

0.53 ± 0.69

[−0.88, 1.79] a

1.02 ± 0.70

[−0.24, 2.51]

Retrospective ADNI-EF

0.51 ± 0.91

[−1.37, 2.25] a

0.28 ± 1.19

[−1.48, 2.12] a

0.78 ± 0.72

[−0.68, 2.47]

1.07 ± 0.79

[−0.56, 2.73]

Baseline ADNI-EF

0.04 ± 1.12

[−2.43, 2.99] a, c

0.62 ± 1.01

[−1.40, 2.00]

0.43 ± 0.88

[−2.78, 2.23] a

0.94 ± 0.87

[−2.31, 2.72]

Prospective ADNI-EF

0.0016 ± 1.19 [−2.91, 2.23] a

0.61 ± 0.83

[−0.83, 1.99]

0.24 ± 0.95

[−2.39, 1.59] a

0.81 ± 0.92

[−2.25, 2.99]

  1. Data are reported as mean ± standard deviation [minimum, maximum]. Hypothesis testing was performed using the Kruskal–Wallis test for the continuous variables and Fisher exact test for the nominal variables. a significantly different from minimal tau pattern; b significantly different from cortical predominant pattern; c significantly different from limbic predominant pattern; AD Alzheimer’s disease; SD standard deviation; TAD typical AD pattern; LP limbic predominant pattern; CP cortical predominant pattern; MT minimal tau pattern; APOE apolipoprotein; MMSE Mini-Mental State Examination; ADNI-MEM composite cognitive scores for memory; ADNI-EF composite cognitive scores for executive function