Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity

Table 1 Characteristics of the study cohort

Diagnosis (baseline)	Healthy (Aβ−)	Cognitively normal (Aβ+)	Prodromal AD (Aβ+)	AD dementia (Aβ+)
N (baseline tau-PET, MRI)	193	98	50	25
N (retrospective MRI)	73	46	31	17
N (prospective MRI)	66	57	42	13
Age at baseline (years)	71.9 ± 6.4 [56, 95]	75.5 ± 7.1 [62, 92]^a	75.3 ± 7.7 [59, 92]^a	78.2 ± 8.2 [56, 91]^a
Sex (% female)	59.6	56.1	52	48
Education (years)	17 ± 2.3 [11, 20]^b	16.7 ± 2.3 [12, 20]^b	15.6 ± 2.6 [12, 20]	15.9 ± 2.6 [12, 20]
*APOE* ε4 carriers (%)^e	23.6	56.7^a	62^a	56^a
MMSE at baseline^f	29.3 ± 1.0 [23, 30]^c	28.8 ± 1.5 [22, 30]^c	27.6 ± 2.3 [19, 30]^d	22 ± 4.2 [9, 30]^d

Data are reported as mean ± standard deviation [minimum, maximum]. Hypothesis testing was performed using the Kruskal–Wallis test for the continuous variables and Fisher exact test for the nominal variables. ^a significantly different from Healthy (Aβ−); ^b significantly different from Prodromal AD; ^c significantly different from Prodromal AD and AD Dementia; ^d significantly different from all other groups; ^e Missing values = 3; ^f Missing values = 2; Aβ β-amyloid; AD Alzheimer’s disease; APOE apolipoprotein; MMSE Mini-Mental State Examination

ISSN: 1758-9193