Skip to main content

Table 4 Univariate analysis of MMP/TIMP ratios in CSF of (pre-)symptomatic D-CAA patients and controls

From: Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy

Pre-symptomatic D-CAA

Symptomatic D-CAA

Ratios MMP/TIMP

n (CAA/CON)

D-CAA

Controls

p -value

Adjusted p -value

n (CAA/CON)

D-CAA

Controls

p -value

Adjusted p -value

MMP-14/TIMP-1

11/21

105.7 (69.8–159.9)

89.2 (72.7–107.0)

p = 0.84 (ns)

p = 0.60 (ns)

11/26

61.2 (51.0–71.4)

78.5 (54.7–103.8)

p = 0.07 (ns)

p  = 0.03 (*)

MMP-14/TIMP-2

11/21

60.1 (48.7–83.3)

58.2 (49.6–79.6)

p = 0.99 (ns)

p = 0.48 (ns)

12/27

43.4 (40.6–55.1)

54.1 (43.3–81.3)

p  = 0.04 (*)

p  = 0.02 (*)

MMP-14/TIMP-3

9/17

27.9 (24.2–34.7)

46.3 (30.8–61.3)

p = 0.05 (ns)

p = 0.18 (ns)

12/25

21.0 (17.3–32.1)

31.8 (22.6–47.8)

p  = 0.04 (*)

p = 0.08 (ns)

  1. Data are presented as median (IQR). Ratios which did not significantly differ (either adjusted or unadjusted) were not presented in this table. p-values for CSF parameters are shown in two variants: (1) unadjusted and (2) adjusted for age of subjects. Nonsignificant (ns) p > 0.05, *p ≤ 0.05. Significant differences are presented in bold and were tested using Mann–Whitney U (all non-parametric data). Group sizes differ per marker because of differences in available sample volumes
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193