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Table 3 Univariate analysis of MMP and TIMP biomarkers in CSF of (pre-)symptomatic D-CAA patients and controls

From: Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy

 

Pre-symptomatic D-CAA

Symptomatic D-CAA

 

n (CAA/CON)

D-CAA

Controls

p -value

Adjusted p -value

n (CAA/CON)

D-CAA

Controls

p -value

Adjusted p -value

Demographics

  Age (y)

11/22

38.0 (31.0–52.0)

45.2 (36.5–51.3)

p = 0.61 (ns)

-

12/28

58.5 (52.8–65.8)

60.3 (51.6–65.9)

p = 0.95 (ns)

-

  Sex, M/F (% male)

11/22

8/3 (73%)

11/11 (50%)

p = 0.28 (ns)

-

12/28

5/7 (41.7%)

17/11 (60.7%)

p = 0.32 (ns)

-

CSF parameters

  MMP-2 (ng/mL)

9/22

22.6 (17.8–25.6)

19.2 (13.2–21.7)

p  = 0.04 (*)

p = 0.18 (ns)

11/28

23.3 (19.2–25.8)

25.8 (20.4–30.4)

p = 0.29 (ns)

p = 0.34 (ns)

  MMP-9 (pg/mL)

10/21

712 (534–1211)

634 (372–764)

p = 0.19 (ns)

p = 0.62 (ns)

12/28

1019 (657–1561)

693 (364–1071)

p = 0.17 (ns)

p = 0.66 (ns)

  MMP-14 (ng/mL)

9/21

2.60 (2.20–3.07)

2.49 (1.95–2.79)

p = 0.31 (ns)

p = 0.98 (ns)

12/28

1.99 (1.76–2.47)

2.57 (1.99–3.58)

p  = 0.03 (*)

p  = 0.02 (*)

  TIMP-1 (ng/mL)

10/22

30.6 (20.0–36.1)

26.0 (20.0–31.3)

p = 0.41 (ns)

p = 0.74 (ns)

12/28

40.2 (27.5–45.9)

35.2 (27.9–40.3)

p = 0.71 (ns)

p = 0.82 (ns)

  TIMP-2 (ng/mL)

10/22

40.4 (34.2–48.1)

40.2 (34.1–46.5)

p = 0.67 (ns)

p = 0.66 (ns)

12/28

46.7 (40.2–52.3)

44.8 (40.7–50.4)

p = 0.68 (ns)

p = 0.71 (ns)

  TIMP-3 (pg/mL)

10/17

87.9 (68.9–116.8)

50.5 (37.2 – 87.1)

p = 0.09 (ns)

p = 0.15 (ns)

12/26

91.3 (57.6–125.4)

87.3 (46.0–120.5)

p = 1.00 (ns)

p = 0.97 (ns)

  Total protein (mg/mL)

11/22

0.71 (0.65–0.84)

0.75 (0.64–0.80)

p = 0.67 (ns)

p = 0.47 (ns)

12/28

0.84 (0.74–0.94)

0.83 (0.68–0.92)

p = 0.81 (ns)

p = 0.90 (ns)

  1. Data are presented as median (IQR). p-values for CSF parameters are shown in two variants: (1) unadjusted and (2) adjusted for age of subjects. Nonsignificant (ns) p > 0.05, *p ≤ 0.05. Significant differences are presented in bold and were tested using Mann–Whitney U (default, in case of non-parametric data) or Student’s T-test (‡, in case of parametric data). Group sizes differ per marker because of differences in available sample volumes