Skip to main content
Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy

Fig. 5

Schematic representation of mechanistic insights into MMP-2, MMP-9 and MMP-14, and, TIMP-1, TIMP-2 and TIMP-3 interactions. TIMP-1, TIMP-2 and TIMP-3 are capable of inhibition of MMP-2, MMP-9 and MMP-14. These MMPs are all capable of cleavage of extracellular matrix (ECM) proteins. Additionally, MMP-14 has a crucial role in the activation of proMMP-2 to MMP-2, a process in which TIMP-2 has an important facilitating function. MMP-2 and MMP-9 and TIMP-1 and TIMP-2 mostly appear as soluble factors, whereas MMP-14 and TIMP-3 are membrane-bound (dashed boxes). Solid lines signify direct, cleavage or inhibition relationships. Dashed lines signify indirect, facilitating roles in the activation of MMP-2

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193