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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy

Fig. 3

Univariate analysis of single MMP and TIMP biomarkers in CSF of (pre-) symptomatic D-CAA patients and controls. In the pre-symptomatic D-CAA group, significant elevations were discovered for MMP-2, compared to their control group (Mann–Whitney U, p = 0.04). In the symptomatic D-CAA group, significant decreases of MMP-14 levels were found, relative to their respective age-matched controls (Mann–Whitney U, p = 0.03). No other significant differences were discovered in biomarker levels between (pre-)symptomatic D-CAA patients and control subjects. Crossed-out symbols signify statistically significant outliers (Grubbs test). Significance levels and accompanying p-values are of uncorrected comparisons. *p < 0.05, ns p > 0.05

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