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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Decreased ratios of matrix metalloproteinases to tissue-type inhibitors in cerebrospinal fluid in sporadic and hereditary cerebral amyloid angiopathy

Fig. 2

Univariate analysis of MMP/TIMP ratios in CSF of sCAA patients and controls. In our discovery groups, significant decreases were discovered in the sCAA group for MMP-2/TIMP-2 (Student’s T-test, p = 0.004), MMP-9/TIMP-2 (Mann–Whitney U, p = 0.002), MMP-14/TIMP-1 (Mann–Whitney U, p = 0.001) and MMP-14/TIMP-2 (Mann–Whitney U, p < 0.001). In the validation groups, significant decreases were discovered in the sCAA group for MMP-2/TIMP-2 (Mann–Whitney U, p = 0.02), MMP-2/TIMP-3 (Mann–Whitney U, p = 0.05), MMP-14/TIMP-2 (Mann–Whitney U, p = 0.04) and MMP-14/TIMP-3 (Mann–Whitney U, p < 0.001). Crossed-out symbols signify statistically significant outliers (Grubbs test). Significance levels and accompanying p-values are of uncorrected comparisons. *p < 0.05, **p < 0.01, ***p < 0.001, ns p > 0.05

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