Table 1 Demographic information of the BABRI and ADNI samples

 No. of participants

65

28

18

–

–

20

24

–

–

 Age, y

64.0 ± 6.8

65.8 ± 5.0

66.2 ± 5.8

− 0.25

0.804

68.0 ± 6.8

63.5 ± 6.4

2.253

0.030

 Male, %

31 (47.7%)

13 (46.4%)

7 (38.9%)

0.253

0.615

11 (55%)

10 (41.7%)

0.777

0.378

 Education, y

11.4 ± 2.9

11.8 ± 2.8

10.9 ± 3.4

0.963

0.341

11.5 ± 4.1

10.1 ± 2.7

1.249

0.221

 MMSE

28.0 ± 1.6

28.5 ± 1.1

26.6 ± 1.8

17.563

< 0.001

25.3 ± 2.8

27.1 ± 1.6

3.585

0.066

 No. Participants

47

47

54

–

–

65

73

–

–

 Age, y

69.3 ± 4.5

73.9 ± 4.3

73.8 ± 3.7

0.134

0.894

74.2 ± 7.7

70.1 ± 8.3

1.663

0.099

 Male, %

23 (48.9%)

23 (48.9%)

26 (48.1%)

0.006

0.937

34 (52.3%)

40 (54.8%)

0.086

0.770

 Education, y

16.5 ± 2.7

15.7 ± 2.9

16.3 ± 2.4

− 1.204

0.231

16.0 ± 2.8

16.7 ± 2.4

− 1.477

0.142

 APOE4 carrier status, %

4.478

0.107

14.331

0.001

  APOE4 heterozygotes

17 (35.4%)

8 (17.0%)

19 (35.2%)

–

–

24 (36.9%)

27 (37.0%)

–

–

  APOE4 homozygotes

1 (2.1%)

2 (4.3%)

1 (1.9%)

–

–

15 (23.1%)

2 (2.7%)

–

–

 MMSE

29.1 ± 1.1

29.2 ± 0.9

28.9 ± 1.2

1.255

0.213

27.0 ± 1.6

28.6 ± 1.5

− 5.911

< 0.001