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Table 2 League table of the changes of overall cognition function: measured with MMSE

From: The beneficial effect on cognition of noninvasive brain stimulation intervention in patients with dementia: a network meta-analysis of randomized controlled trials

HF-rTMS-F3F4

   

*4.13 (0.29, 7.98)

     

*6.11 (2.62, 9.59)

 

0.56 (−3.59, 4.71)

c-tDCS-F3 + a-tDCS-Fp2

0.94 (−0.31, 2.19)

       

*5.55 (4.28, 6.82)

 

1.50 (−2.67, 5.66)

0.94 (−0.88, 2.76)

a-tDCS-F3 + c-tDCS-Fp2

       

*4.61 (3.30, 5.93)

 

3.72 (−0.47, 7.92)

*3.17 (0.50, 5.83)

2.23 (−0.46, 4.91)

a-tDCS-F7 + c-tDCS-Fp2

      

2.47 (−0.15, 5.09)

 

*4.13 (0.07, 8.20)

3.58 (−0.40, 7.56)

2.64 (−1.36, 6.63)

0.41 (−3.62, 4.44)

LF-rTMS-F3F4

     

1.97 (−1.31, 5.26)

 

4.34 (−0.01, 8.68)

*3.78 (0.88, 6.67)

2.84 (−0.08, 5.76)

0.61 (−2.35, 3.57)

0.20 (−3.99, 4.39)

HF-rTMS-F3T3

    

1.77 (−0.05, 3.59)

 

*5.40 (1.08, 9.72)

*4.85 (1.99, 7.70)

*3.91 (1.03, 6.78)

1.68 (−1.24, 4.60)

1.27 (−2.89, 5.43)

1.07 (−2.07, 4.20)

HF-rTMS-F3

  

1.64 (−3.62, 6.91)

0.55 (−1.60, 2.70)

 

5.51 (−0.28, 11.29)

*4.95 (0.16, 9.74)

4.01 (−0.79, 8.81)

1.78 (−3.05, 6.62)

1.37 (−4.29, 7.04)

1.17 (−3.79, 6.14)

0.10 (−4.83, 5.04)

a-tDCS-F3 + c-tDCS-F4

  

0.60 (−3.63, 4.83)

 

6.11 (−2.32, 14.54)

5.55 (−2.23, 13.33)

4.61 (−3.18, 12.40)

2.38 (−5.42, 10.19)

1.97 (−6.38, 10.32)

1.77 (−6.12, 9.66)

0.70 (−7.17, 8.58)

0.60 (−8.17, 9.37)

a-tDCS-T3 + c-tDCS-Fp2

 

0.00 (−7.45, 7.45)

 

*6.12 (1.70, 10.55)

*5.57 (2.56, 8.57)

*4.63 (1.60, 7.65)

2.40 (−0.70, 5.50)

1.99 (−2.28, 6.26)

1.79 (−1.49, 5.06)

0.72 (−2.23, 3.67)

0.62 (−4.42, 5.65)

0.02 (−7.92, 7.95)

HF-rTMS-Mx

0.20 (−2.37, 2.77)

 

*6.11 (2.38, 9.83)

*5.55 (3.72, 7.38)

*4.61 (2.75, 6.47)

*2.38 (0.45, 4.32)

1.97 (−1.56, 5.51)

1.77 (−0.47, 4.02)

0.70 (−1.48, 2.89)

0.60 (−3.83, 5.03)

−0.00 (−7.56, 7.56)

−0.02 (−2.40, 2.37)

Sham

1.40 (−1.03, 3.83)

*7.51 (2.87, 12.15)

*6.95 (3.63, 10.27)

*6.01 (2.67, 9.35)

*3.78 (0.41, 7.16)

3.37 (−1.12, 7.86)

3.17 (−0.39, 6.73)

2.10 (−1.42, 5.63)

2.00 (−3.22, 7.22)

1.40 (−6.65, 9.45)

1.38 (−2.27, 5.04)

1.40 (−1.37, 4.17)

a-tDCS-F3 + c-tDCS-RtLb

  1. Pairwise (upper-right portion) and network (lower-left portion) meta-analysis results are presented as estimate effect sizes for the outcome of changes of cognition function in measurement of MMSE in patients with Alzheimer’s dementia. Interventions are reported in order of mean ranking of beneficial effect on cognition function in measurement of MMSE, and outcomes are expressed as mean difference (MD) (95% confidence intervals). For the pairwise meta-analyses, MD of more than 0 indicate that the treatment specified in the row got more beneficial effect than that specified in the column. For the network meta-analysis (NMA), MD of more than 0 indicate that the treatment specified in the column got more beneficial effect than that specified in the row. Bold results marked with * indicate statistical significance
  2. Abbreviations: HF-rTMS-F3F4, high-frequency rTMS over bilateral DLPFC; c-tDCS-F3 + a-tDCS-Fp2, cathodal tDCS of the left DLPFC and anodal over the right supraorbital region; a-tDCS-F3 + c-tDCS-Fp2, anodal tDCS of the left DLPFC and cathodal over the right supraorbital region; a-tDCS-F7 + c-tDCS-Fp2, anodal tDCS of the left frontotemporal lobe and cathodal over the right frontal lobe; LF-rTMS-F3F4, low frequency rTMS over bilateral DLPFC; HF-rTMS-F3T3, high-frequency rTMS over left DLPFC and left lateral temporal lobe; HF-rTMS-F3, high-frequency rTMS over left DLPFC; a-tDCS-F3 + c-tDCS-F4, anodal tDCS of the left DLPFC and cathodal over the right DLPFC; a-tDCS-T3 + c-tDCS-Fp2, anodal tDCS of the left lateral temporal lobe and cathodal over the right frontal lobe; HF-rTMS-Mx, high-frequency rTMS multifocal stimulation; a-tDCS-F3 + c-tDCS-RtLb, anodal tDCS of the left DLPFC and cathodal over the right deltoid muscle; MMSE: mini-mental state examination; DLPFC, dorsolateral prefrontal cortex; rTMS, repetitive transcranial magnetic stimulation; Sham, sham control; tDCS, transcranial direct current stimulation
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Alzheimer's Research & Therapy

ISSN: 1758-9193