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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice

Fig. 7

Decreased anxiety and impaired spatial learning in 12-month-old 5xFAD and 5xFADxhtau-KI mice compared to WT and htau-KI mice. a,b Results of the elevated plus maze do not show significant differences at the age of 6 months (a), but at the age of 12 months, the time spent on open arms in 5xFAD and 5xFADxhtau-KI mice is significantly different compared to WT and htau-KI (b). Mean ± SEM. One-way ANOVA with Tukey’s post hoc test, *P < 0.05, **P < 0.01, ***P < 0.001, 6 months: WT (n=23), 5xFAD (n=23), htau-KI (n=20), 5xFADxhtau-KI (n=20) (male and female); 12 months: WT (n=22), 5xFAD (n=21), htau-KI (n=23), 5xFADxhtau-KI (n=18) (male and female). c,d Latency to find a hidden platform in the Morris water maze analyzed in 6-month-old (c) and 12-month-old (d) animals. While there was no significant interaction of genotype and trial days on latency in 6-month-old mice (all P-values >0.05), we found a significant interaction of genotype and trial on slope of latency curves of 5xFAD mice compared to 5xFADxhtau-KI mice and htau-KI mice, respectively (5xFAD vs. 5xFADxhtau-KI: P=.0.035; 5xFAD vs. htau-KI: P= 0.014). Each data point represents the mean ± SEM of 4 trials per day. P-values from RM-ANOVA using slopes of learning curves are depicted in the Fig. 6 months: WT (n=23), 5xFAD (n=24), htau-KI (n=21), 5xFADxhtau-KI (n=20) (male and female); 12 months: WT (n=24), 5xFAD (n=23), htau-KI (n=24), 5xFADxhtau-KI (n=19) (male and female)

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