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Table 3 MRI volumes (mean±SEM) of medial temporal lobe–specific regions, according to APOE genotype status and HRT use

From: Hormone replacement therapy is associated with improved cognition and larger brain volumes in at-risk APOE4 women: results from the European Prevention of Alzheimer’s Disease (EPAD) cohort

 

Non-E4

E4

PAPOE

PHRT

PAPOE*HRT

 

No-HRT (n=591–593)

HRT (n=48–50)

Total (n=639–643)

p-HRT

No-HRT (n=345–347)

HRT (n=29)

Total (n=374–376)

p-HRT

   

Right hippocampus

2360 ±13

2383 ±60

2362 ±13

0.367

2298 ±22

2384 ±37

2304 ±21

0.568

0.903

0.920

0.313

Left hippocampus

2284 ±13

2335 ±57

2288 ±12

0.690

2227 ±22

2333 ±43

2235 ±20

0.378

0.889

0.652

0.345

Right parahippocampal

2670 ±13

2735 ±50

2675 ±13

0.693

2624 ±20

2670 ±52

2628 ±19

0.370

0.430

0.660

0.966

left parahippocampal

2930 ±15

2971 ±46

2933 ±14

0.602

2840 ±20

2946 ±59

2849 ±19

0.801

0.587

0.698

0.302

Right entorhinal

2422 ±15

2444 ±53

2426 ±14

0.943

2378 ±22

2529 ±69

2373 ±22

0.040 a

0.432

0.116

0.074

Left entorhinal

2026 ±12

2014 ±43

2029 ±12

0.426

1967 ±17

2172 ±55

1974 ±17

<0.001

0.106

0.026 a

0.002

Right amygdala

1031 ±07

987 ±21

1029 ±06

0.030a

1002 ±11

1062 ±31

999 ±10

0.063

0.178

0.888

0.005

Left amygdala

1073 ±07

1038 ±23

1072 ±06

0.039a

1039 ±10

1105 ±33

1038 ±10

0.031 a

0.204

0.661

0.003

Ventricular volume

25444 ±814

22262 ±1725

25201 ±763

0.949

24244 ±825

24265 ±3507

24245 ±805

0.860

0.987

0.858

0.920

Right cerebral WMV

10951 ±106

11287 ±351

10977 ±102

0.658

10697 ±140

10584 ±510

10688 ±135

0.291

0.908

0.266

0.576

Left cerebral WMV

11052 ±120

11408 ±372

11080 ±114

0.764

10847 ±146

10581 ±467

10826 ±140

0.961

0.630

0.886

0.842

  1. Mean (mm3) ±SEM of medial temporal lobe–specific MRI brain volumes, according to APOE4 genotype and HRT use. Significant P values for APOE genotype, HRT, and APOE*HRT are shown. MANCOVA model was used. p-HRT within each APOE genotype is calculated using the pairwise comparison of estimated marginal mean with Bonferroni adjustment for multiple comparison. Adjustment of the brain regions to the whole brain volume was carried out before statistical analysis. Age, years of education, marital status, handedness, and CDR were used as covariates. p-significant <0.05. a insignificant after FDR correction for multiple comparison. Bold: significant after FDR correction. WMV white matter volume