Feature | HC | Relatives | SCD | MCI | DAT | p |
---|---|---|---|---|---|---|
n = 74 | n = 23 | n = 99 | n = 75 | n = 38 | ||
Age (yrs.), median (SD) | 68 (5) | 64 (4) | 71 (6) | 73 (5) | 75 (7) | 2 × 10E−10 |
Sex (male), n (%) | 40 (54) | 17 (74) | 44 (44) | 23 (31) | 25 (63) | 4 × 10E−4 |
APOE (ε4 positive), n (%) | 16 (22) | 8 (35) | 35 (35) | 29 (39) | 25 (66) | 3 × 10E−4 |
BMI, median (SD) | 25 (3) | 26 (4) | 25 (3) | 26 (4) | 24 (4) | 0.084 |
Aβ42/40, median (SD) | 0.097 (0.021) | 0.100 (0.024) | 0.095 (0.027) | 0.066 (0.030) | 0.046 (0.017) | 9 × 10E−15 |
Aβ42/40 < 0.08, n (%) | 17 (23) | 4 (17) | 36 (36) | 43 (57) | 35 (92) | 7 × 10E−13 |
t-tau (pg/ml), median (SD) | 368 (159) | 372 (104) | 368 (192) | 483 (262) | 804 (342) | 7 × 10E−13 |
t-tau > 510.9, n (%) | 15 (20) | 3 (13) | 21 (21) | 34 (45) | 31 (82) | 2 × 10E−12 |
p-tau-181 (pg/ml), median (SD) | 49.4 (18.4) | 43.4 (12.1) | 47.3 (24.4) | 63.2 (31.7) | 87.5 (39.6) | 5 × 10E−10 |
p-tau-181 > 73.65, n (%) | 8 (8) | 0 (0) | 12 (12) | 24 (32) | 28 (74) | 6 × 10E−17 |
A− T−, n (%) | 55 (74.3) | 19 (82.6) | 60 (60.6) | 30 (40.5) | 3 (7.9) | 3 × 10E−17 |
A− T+, n (%) | 2 (2.7) | 0 (0.0) | 3 (3.0) | 2 (2.7) | 0 (0.0) | |
A+ T−, n (%) | 13 (17.6) | 4 (17.4) | 27 (27.3) | 20 (27.0) | 7 (18.4) | |
A+ T+, n (%) | 4 (5.4) | 0 (0.0) | 9 (9.1) | 22 (29.7) | 28 (73.7) | |
PACC5 score, median (SD) | 0.57 (0.41) | 0.31 (0.65) | 0.38 (0.50) | −0.74 (0.64) | −1.93 (0.57) | < 1 × 10E−15 |
Mean follow-up time (yrs., SD) | 3.5 (1.1) | 3.0 (1.4) | 3.5 (1.3) | 2.7 (1.4) | 2.0 (1.4) | 2 × 10E−6 |
Braak I, median (SD) | 0.28 (0.66) | 0.43 (0.46) | 0.28 (0.73) | −0.05 (1.21) | −1.14 (1.05) | 6 × 10E−12 |
Braak II, median (SD) | 0.43 (0.72) | 0.41 (0.73) | 0.34 (0.74) | −0.37 (0.95) | −1.52 (0.92) | < 1 × 10E−15 |
Braak III, median (SD) | 0.32 (0.55) | 0.25 (0.47) | 0.28 (0.50) | −0.32 (0.67) | −0.55 (0.94) | 5 × 10E−14 |
Braak IV, median (SD) | 0.29 (0.51) | 0.25 (0.44) | 0.07 (0.48) | −0.28 (0.66) | −0.58 (0.80) | 6 × 10E−12 |
Braak V, median (SD) | 0.30 (0.48) | 0.43 (0.40) | 0.13 (0.53) | −0.24 (0.65) | −0.55 (0.79) | 3 × 10E−11 |
Braak VI, median (SD) | 0.11 (0.72) | 0.25 (0.67) | 0.05 (0.65) | −0.34 (0.80) | −0.04 (0.98) | 0.001 |