Table 2 Regression results for the different PRS and amyloid rate of change. Raw values are shown, significant p-values in bold (< 0.017 (multiple pT) or < 0.05 (for single score)). APOE region: chromosome 19: 45–48.8 Mb. APOE SNPs: rs429358, rs7412. Baseline age, sex, and PCs 1–3 included as covariates. N = 90
Score | Score description | pT | Number of SNPs | Adjusted R2 | PRS p-value | PRS β (95% CI) |
|---|---|---|---|---|---|---|
PRSnoAPOE+APOEε2+ε4 | All available SNPs at each pT excluding the APOE region, plus the weighted sum of the two major APOE SNPs | 5 × 10−8 | 22 | 0.12 | 0.0126 | 0.68 (0.15–1.20) |
1 × 10−5 | 70 | 0.08 | 0.1188 | 0.45 (− 0.12–1.02) | ||
0.1 | 77,270 | 0.06 | 0.4319 | 0.21 (− 0.32–0.74) | ||
PRSAD | All available SNPs at each pT | 5 × 10−8 | 65 | 0.09 | 0.0721 | 0.48 (− 0.04–1.01) |
1 × 10−5 | 129 | 0.07 | 0.1895 | 0.36 (− 0.18–0.89) | ||
0.1 | 77,378 | 0.05 | 0.6874 | − 0.10 (− 0.61–0.40) | ||
APOEε2+ε4 | Weighted sum of the two major APOE SNPs | 2 | 0.09 | 0.0496 | 0.55 (0.0009–1.09) | |
PRSnoAPOE | All available SNPs at each pT excluding the APOE region | 5 × 10−8 | 20 | 0.08 | 0.1262 | 0.37 (− 0.10–0.84) |
1 × 10−5 | 68 | 0.05 | 0.7016 | 0.10 (− 0.43–0.64) | ||
0.1 | 77,268 | 0.05 | 0.5510 | − 0.15 (− 0.66–0.35) | ||
PRSAPOEonly | All available SNPs within the APOE region at each pT | 5 × 10−8 | 46 | 0.07 | 0.1455 | 0.39 (− 0.14–0.91) |
1 × 10−5 | 62 | 0.07 | 0.2191 | 0.33 (− 0.20–0.86) | ||
0.1 | 118 | 0.06 | 0.2885 | 0.29 (−0.25–0.82) |