Institutionalization | Mortality | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
Univariable | Model 1 | Model 2 | Univariable | Model 1 | Model 2 | |||||
Age and sex adjusted | Without CSF | Without CSF/MRI | Age and sex adjusted | Without CSF | Without CSF/MRI | |||||
Age | 1.09* (1.05; 1.13) | 1.10* (1.06; 1.14) | 1.03 (1.00; 1.07) | 1.07 (1.02; 1.11) | 1.10 (1.06; 1.14) | 1.12* (1.09; 1.16) | 1.12* (1.09; 1.15) | 1.04 (1.00; 1.07) | 1.06 (1.02; 1.09) | 1.08 (1.05; 1.12) |
Sex, female | 1.21 (0.73; 2.00) | 1.35 (0.81; 2.23) | 1.52 (0.98; 2.60) | 1.67 (1.00; 2.83) | 1.56 (0.92; 2.63) | 0.72 (0.49; 1.06) | 0.75 (0.51; 1.10) | 0.97 (0.64; 1.45) | 0.96 (0.65; 1.43) | 0.88 (0.59; 1.32) |
MMSE | 0.83* (0.77; 0.90) | 0.83* (0.76; 0.91) | 0.91 (0.83; 1.00) | 0.84 (0.77; 0.91) | 0.84 (0.77; 0.92) | 0.94 (0.88; 1.01) | 0.95 (0.88; 1.02) | |||
NPI | 1.03* (1.00; 1.06) | 1.03* (1.01; 1.06) | 1.03 (1.00; 1.06) | 1.03 (1.00; 1.06) | 1.03* (1.01; 1.05) | 1.02* (1.00; 1.04) | 1.02 (1.00; 1.04) | 1.02 (1.00; 1.04) | ||
CCI | 1.22* (1.07; 1.39) | 1.00 (0.81; 1.23) | 1.50* (1.38; 1.63) | 1.29* (1.15; 1.46) | 1.27 (1.12; 1.43) | 1.23 (1.09; 1.39) | 1.28 (1.14; 1.45) | |||
APOE e4 | 1.96* (1.18; 3.27) | 1.91* (1.15; 3.19) | 1.67 (1.00; 2.79) | 1.85 (1.10; 3.09) | 1.36 (0.94; 1.96) | 1.32 (0.91; 1.90) | ||||
GCA | 2.74* (1.92; 3.92) | 2.21* (1.45; 3.36) | 2.08 (1.34; 3.23) | 2.08 (1.32; 3.26) | 2.93* (2.27; 3.80) | 1.89* (1.39; 2.56) | 1.39 (0.97; 1.97) | 1.46 (1.03; 2.06) | ||
MTA | 1.89* (1.34; 2.58) | 1.36 (0.91; 2.04) | 2.52* (2.04; 3.12) | 1.76* (1.37; 2.27) | 1.50 (1.11; 2.01) | 1.44 (1.08; 1.93) | ||||
WMH | 1.60* (1.20; 2.13) | 1.25 (0.91; 1.71) | 1.47* (1.19; 1.82) | 1.08 (0.85; 1.37) | ||||||
CSF Aβ42a | 0.85* (0.80; 0.90) | 0.87* (0.82; 0.92) | 0.90 (0.84; 0.96) | 0.92* (0.89; 0.96) | 0.95* (0.92; 0.99) | 0.96 (0.92; 1.00) | ||||
CSF p-tau | 1.05* (1.04; 1.06) | 1.04* (1.02; 1.05) | 1.02 (1.01; 1.04) | 1.03* (1.02; 1.04) | 1.02* (1.00; 1.03) | 1.02 (1.00; 1.03) | ||||
Harrell’s C | 0.81 (0.76; 0.86) | 0.76 (0.71; 0.82) | 0.76 (0.70; 0.82) | 0.79 (0.75; 0.83) | 0.79 (0.75; 0.83) | 0.76 (0.71; 0.80) | ||||
3-year Brier score | 0.015 (0.008; 0.021) | 0.015 (0.008; 0.021) | 0.015 (0.008; 0.021) | 0.024 (0.016; 0.032) | 0.0244 (0.016; 0.032) | 0.024 (0.016; 0.032) |