Skip to main content
Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Krüppel-like factor 5 accelerates the pathogenesis of Alzheimer’s disease via BACE1-mediated APP processing

Fig. 2

KLF5 and BACE1 expression levels increase in APP/PS1 mice and are associated with cognitive function. A mRNA levels of KLF5 and BACE1 in the cerebral cortex of APP/PS1 mice (n = 6) and WT mice (n = 6). B mRNA levels of KLF5 and BACE1 in the hippocampus of APP/PS1 mice (n = 6) and WT mice (n = 6). C Representative Western blots of the protein expression levels of KLF5 (upper panel) and BACE1 (middle panel) in the cerebral cortex of APP/PS1 mice and WT mice. D Relative quantification of the protein levels of KLF5 and BACE1 in the cerebral cortex of APP/PS1 mice (n = 6) and WT mice (n = 6). E Representative Western blots of the protein expression levels of KLF5 (upper panel) and BACE1 (middle panel) in the hippocampus of APP/PS1 mice and WT mice. F Relative quantification of the protein levels of KLF5 and BACE1 in the hippocampus of APP/PS1 mice (n = 6) and WT mice (n = 6). G Relationship between the protein levels of KLF5 (X-axis) and BACE1 (Y-axis) in the brain of the mice (n = 12). H Immunofluorescence laser confocal microscopy of the expression and sublocalization of KLF5 and BACE1 in the brain of APP/PS1 mice and WT mice. Data in A, B, D, and F are mean ± s.e.m (*P < 0.05, **P < 0.01, ****P < 0.0001; t-test). Data in G are examined through linear regression analysis

Back to article page