|  | Presymptomatic C9orf72 | Symptomatic C9orf72 | Presymptomatic GRN | Symptomatic GRN | Presymptomatic MAPT | Symptomatic MAPT | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho | p-value | Rho | p-value | Rho | p-value | Rho | p-value | Rho | p-value | Rho | p-value | ||
NPTXR NNYMYAR | Total brain | 0.42 | 0.025 | 0.23 | 0.365 | 0.14 | 0.532 | 0.48 | 0.161 | 0.24 | 0.303 | 0.66 | 0.157 |
Frontal | 0.19 | 0.321 | 0.41 | 0.090 | 0.53 | 0.011 | 0.73 | 0.017 | 0.15 | 0.522 | 0.81 | 0.053 | |
Temporal | 0.50 | 0.006 | 0.14 | 0.588 | 0.30 | 0.182 | 0.77 | 0.009 |  − 0.06 | 0.810 | 0.30 | 0.564 | |
Parietal | 0.11 | 0.571 | 0.10 | 0.704 | 0.52 | 0.014 | 0.51 | 0.131 | 0.17 | 0.483 | 0.64 | 0.170 | |
NfL | 0.00 | 0.994 |  − 0.68 | 0.005 | 0.02 | 0.925 | 0.08 | 0.821 |  − 0.14 | 0.572 | 0.94 | 0.016 | |
CDR plus NACC FTLD |  − 0.38 | 0.044 |  − 0.29 | 0.248 | 0.00 | 0.997 |  − 0.28 | 0.425 | 0.19 | 0.422 |  − 0.21 | 0.697 | |
NPTX1 CESQSTLDPGAGEAR | Total brain | 0.36 | 0.052 | 0.11 | 0.654 | 0.34 | 0.118 | 0.17 | 0.633 | 0.23 | 0.327 | 0.40 | 0.427 |
Frontal lobe | 0.25 | 0.183 | 0.06 | 0.812 | 0.52 | 0.012 | 0.42 | 0.225 | 0.00 | 0.996 | 0.54 | 0.264 | |
Temporal lobe | 0.20 | 0.300 |  − 0.05 | 0.833 | 0.41 | 0.058 | 0.40 | 0.255 |  − 0.09 | 0.711 | 0.01 | 0.984 | |
Parietal lobe | 0.41 | 0.029 |  − 0.24 | 0.345 | 0.59 | 0.004 | 0.44 | 0.205 | 0.08 | 0.740 | 0.50 | 0.315 | |
NfL | 0.04 | 0.856 |  − 0.51 | 0.051 | 0.07 | 0.757 |  − 0.22 | 0.539 |  − 0.46 | 0.040 | 0.54 | 0.348 | |
CDR plus NACC FTLD | 0.10 | 0.601 |  − 0.07 | 0.770 |  − 0.12 | 0.593 | 0.06 | 0.870 |  − 0.01 | 0.961 |  − 0.45 | 0.373 | |
NPTX2 VAELEDEK | Total brain | 0.38 | 0.045 | 0.38 | 0.120 | 0.25 | 0.257 | 0.50 | 0.145 | 0.31 | 0.189 | 0.95 | 0.004 |
Frontal lobe | 0.21 | 0.277 | 0.60 | 0.008 | 0.41 | 0.059 | 0.80 | 0.006 | 0.16 | 0.489 | 0.80 | 0.054 | |
Temporal lobe | 0.49 | 0.007 | 0.42 | 0.080 | 0.20 | 0.377 | 0.65 | 0.043 | 0.12 | 0.623 | 0.75 | 0.085 | |
Parietal lobe | 0.18 | 0.343 | 0.27 | 0.274 | 0.45 | 0.035 | 0.50 | 0.141 | 0.11 | 0.657 | 0.67 | 0.148 | |
NfL | 0.05 | 0.786 |  − 0.48 | 0.073 | 0.06 | 0.781 |  − 0.08 | 0.837 |  − 0.03 | 0.886 | 0.67 | 0.215 | |
CDR plus NACC FTLD |  − 0.37 | 0.048 |  − 0.49 | 0.041 | 0.00 | 0.989 |  − 0.24 | 0.497 | 0.18 | 0.436 |  − 0.60 | 0.204 |