Scenario | Parameter | Parameter description | Parameter value | AD-mediated pathology | ||
---|---|---|---|---|---|---|
Control condition | AD-like scenario | Contrast scenario | ||||
Pyramidal neuronal hyperactivity | ||||||
1A | Vd1 | Threshold potential of excitatory populations | 7 | 6 | 8 | A lower Vd1 value causes the excitatory populations to become hyperexcitable |
1B | he(t) function (a1 and b1) | Excitatory post-synaptic potential (EPSP) | a1: 55 b1: 605 | a1: 48 b1: 540 | a1: 62 b1: 670 | Increasing parameters a and b of the he(t) function will increase the postsynaptic excitatory amplitude and duration of both the excitatory and inhibitory populations |
1C | S | Global coupling factor | 1.5 | 2.0 | 1.0 | A higher global coupling factor results in stronger excitatory output (E(t)) multiplication and thus increased excitatory innervation of the excitatory population in the coupled neural masses |
Inhibitory neuronal dysfunction | ||||||
2A | Vd2 | Threshold potential of inhibitory populations | 7 | 8 | 6 | A higher Vd2 value causes the inhibitory populations to become hypoexcitable |
2B | hi(t) function (a2 and b2) | Inhibitory post-synaptic potential (IPSP) | a2: 27.5 b2: 55 | a2: 40 b2: 70 | a2: 17.5 b2: 35 | Higher values of parameters a and b of the hi(t) function will decrease the postsynaptic inhibitory amplitude and duration in the excitatory populations |
2C | C2 | Coupling from inhibitory to excitatory populations | 3 | 2 | 4 | A lower C2 value will decrease the inhibitory to excitatory coupling |