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Table 3 Differences in protein levels between p-tau subgroups, corrected for age and sex

From: P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles

Protein (Z-score)

Controls (n = 98)

Protein level per p-tau group: mean ± standard error of the mean (SE)

Contrasts between p-tau subgroups

Differences between p-tau subgroups: mean ± SE

p-values of contrasts

Subgroup 1: p-tau ≤ 56 pg/ml (n = 94)

Subgroup 2: p-tau 57–96 pg/ml (n = 147)

Subgroup 3: p-tau 97–159 pg/ml (n = 89)

Subgroup 4: p-tau > 159 pg/ml (n = 11)

1 vs control

2 vs 1

3 vs 1

4 vs 1

3 vs 2

4 vs 2

4 vs 3

1 vs control

2 vs 1

3 vs 1

4 vs 1

3 vs 2

4 vs 2

4 vs 3

BACE1 (n = 439)

0.11 ± 0.1

-0.46 ± 0.09

0.58 ± 0.07

1.44 ± 0.1

2.58 ± 0.27

− 0.57 ± 0.13

1.05 ± 0.12

1.9 ± 0.13

3.04 ± 0.29

0.85 ± 0.12

1.99 ± 0.28

1.14 ± 0.28

1.1E−04

0.0E+00

0.0E+00

0.0E+00

4.1E−11

2.6E−11

4.6E−04

Aβ40 (n = 439)

0.18 ± 0.1

-0.82 ± 0.1

0.32 ± 0.08

1.16 ± 0.1

1.67 ± 0.29

− 0.99 ± 0.14

1.14 ± 0.13

1.98 ± 0.15

2.49 ± 0.31

0.84 ± 0.13

1.35 ± 0.3

0.51 ± 0.31

9.6E−11

0.0E+00

0.0E+00

8.3E−14

3.5E−09

8.2E−05

0.513

NfL (n = 436)

0.13 ± 0.09

0.76 ± 0.09

1.22 ± 0.07

1.83 ± 0.09

2.36 ± 0.25

0.63 ± 0.12

0.47 ± 0.11

1.07 ± 0.12

1.6 ± 0.26

0.61 ± 0.11

1.14 ± 0.26

0.53 ± 0.26

2.8E−06

1.6E−04

7.8E−16

1.6E−08

4.9E−07

8.2E−05

0.262

VAMP2 (n = 396)

0.12 ± 0.1

-0.62 ± 0.1

0.67 ± 0.08

1.64 ± 0.1

2.9 ± 0.29

− 0.74 ± 0.14

1.29 ± 0.13

2.25 ± 0.15

3.52 ± 0.31

0.97 ± 0.13

2.23 ± 0.3

1.27 ± 0.31

2.3E−06

0.0E+00

0.0E+00

0.0E+00

5.7E−12

6.6E−12

3.1E−04

NRGN (n = 439)

0.1 ± 0.09

0.03 ± 0.08

1.41 ± 0.07

2.43 ± 0.09

3.92 ± 0.24

− 0.07 ± 0.12

1.37 ± 0.11

2.4 ± 0.12

3.89 ± 0.26

1.02 ± 0.11

2.51 ± 0.25

1.49 ± 0.26

0.997

0.0E+00

0.0E+00

0.0E+00

0.0E+00

0.0E+00

7.1E−08

  1. Protein levels were natural log-transformed and standardized relative to cognitively normal individuals with normal CSF amyloid, t-tau, and p-tau (controls). Age- and sex-adjusted differences in protein levels between p-tau subgroups were calculated with linear models. p-values of comparisons between p-tau subgroups were adjusted with the Sidak method (considered significant at p-value < 0.05)
  2. CSF, cerebrospinal fluid; BACE1, beta-site amyloid precursor protein cleaving enzyme 1; Aβ40, amyloid-beta 1–40; NfL, neurofilament light; NRGN, neurogranin; VAMP2, vesicle-associated membrane protein 2