From: P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles
Protein (Z-score) | Controls (n = 98) | Protein level per p-tau group: mean ± standard error of the mean (SE) | Contrasts between p-tau subgroups | ||||||||||||||||
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Differences between p-tau subgroups: mean ± SE | p-values of contrasts | ||||||||||||||||||
Subgroup 1: p-tau ≤ 56 pg/ml (n = 94) | Subgroup 2: p-tau 57–96 pg/ml (n = 147) | Subgroup 3: p-tau 97–159 pg/ml (n = 89) | Subgroup 4: p-tau > 159 pg/ml (n = 11) | 1 vs control | 2 vs 1 | 3 vs 1 | 4 vs 1 | 3 vs 2 | 4 vs 2 | 4 vs 3 | 1 vs control | 2 vs 1 | 3 vs 1 | 4 vs 1 | 3 vs 2 | 4 vs 2 | 4 vs 3 | ||
BACE1 (n = 439) | 0.11 ± 0.1 | -0.46 ± 0.09 | 0.58 ± 0.07 | 1.44 ± 0.1 | 2.58 ± 0.27 | − 0.57 ± 0.13 | 1.05 ± 0.12 | 1.9 ± 0.13 | 3.04 ± 0.29 | 0.85 ± 0.12 | 1.99 ± 0.28 | 1.14 ± 0.28 | 1.1E−04 | 0.0E+00 | 0.0E+00 | 0.0E+00 | 4.1E−11 | 2.6E−11 | 4.6E−04 |
Aβ40 (n = 439) | 0.18 ± 0.1 | -0.82 ± 0.1 | 0.32 ± 0.08 | 1.16 ± 0.1 | 1.67 ± 0.29 | − 0.99 ± 0.14 | 1.14 ± 0.13 | 1.98 ± 0.15 | 2.49 ± 0.31 | 0.84 ± 0.13 | 1.35 ± 0.3 | 0.51 ± 0.31 | 9.6E−11 | 0.0E+00 | 0.0E+00 | 8.3E−14 | 3.5E−09 | 8.2E−05 | 0.513 |
NfL (n = 436) | 0.13 ± 0.09 | 0.76 ± 0.09 | 1.22 ± 0.07 | 1.83 ± 0.09 | 2.36 ± 0.25 | 0.63 ± 0.12 | 0.47 ± 0.11 | 1.07 ± 0.12 | 1.6 ± 0.26 | 0.61 ± 0.11 | 1.14 ± 0.26 | 0.53 ± 0.26 | 2.8E−06 | 1.6E−04 | 7.8E−16 | 1.6E−08 | 4.9E−07 | 8.2E−05 | 0.262 |
VAMP2 (n = 396) | 0.12 ± 0.1 | -0.62 ± 0.1 | 0.67 ± 0.08 | 1.64 ± 0.1 | 2.9 ± 0.29 | − 0.74 ± 0.14 | 1.29 ± 0.13 | 2.25 ± 0.15 | 3.52 ± 0.31 | 0.97 ± 0.13 | 2.23 ± 0.3 | 1.27 ± 0.31 | 2.3E−06 | 0.0E+00 | 0.0E+00 | 0.0E+00 | 5.7E−12 | 6.6E−12 | 3.1E−04 |
NRGN (n = 439) | 0.1 ± 0.09 | 0.03 ± 0.08 | 1.41 ± 0.07 | 2.43 ± 0.09 | 3.92 ± 0.24 | − 0.07 ± 0.12 | 1.37 ± 0.11 | 2.4 ± 0.12 | 3.89 ± 0.26 | 1.02 ± 0.11 | 2.51 ± 0.25 | 1.49 ± 0.26 | 0.997 | 0.0E+00 | 0.0E+00 | 0.0E+00 | 0.0E+00 | 0.0E+00 | 7.1E−08 |