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Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profiles

Fig. 4

Associations of p-tau subgroups with protein levels in CN amyloid-negative individuals. CN amyloid-negative individuals included both individuals with normal t-tau and p-tau (controls) and individuals with abnormal t- or p-tau (suspected non-Alzheimer’s disease pathology or SNAP). Protein levels were Z-scored relative to controls. The box of the boxplot indicates the 25th percentile, median, and 75th percentile, and whiskers indicate the 1.5× interquartile range. Arrows indicate the protein measurements outside of the y-axis. Differences between p-tau subgroups in the protein levels were calculated with linear models adjusted for age and sex. p-values were adjusted for the multiple comparisons between p-tau subgroups with the Sidak method. BACE1, beta-site amyloid precursor protein cleaving enzyme 1; Aβ40, amyloid-beta 1–40; NfL, neurofilament light; VAMP2, vesicle-associated membrane protein 2; NRGN, neurogranin. *p-value < 0.05; **p-value < 0.01; ***p-value < 0.001; n.s., not significant

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