Fig. 1From: P-tau subgroups in AD relate to distinct amyloid production and synaptic integrity profilesOverview of the study design. Among amyloid abnormal individuals, previously established p-tau subgroups [4] were compared in markers reflecting other AD-related processes: Aβ40 and BACE1 (reflecting amyloid metabolism), NfL (reflecting axonal damage), and VAMP2 and NRGN (reflecting synaptic integrity). The density distribution of p-tau subgroups was adapted from previous research [4]. Aβ40, amyloid-beta 1–40; APP, amyloid precursor protein; BACE1, beta-site amyloid precursor protein cleaving enzyme 1; γ-secr., γ-secretase; NfL, neurofilament light; NRGN, neurogranin; VAMP2, vesicle-associated membrane protein 2Back to article page