Table 4 Influence of regional amyloid deposition on conversion to dementia (ADNI dataset)
|  | Cutoff SUVR | AUC | Sensitivity (%) | Specificity (%) | P value | DeLong’s test P value |
|---|---|---|---|---|---|---|
Bilateral frontal | 1.1726 | 0.582 (0.412–0.753) | 63.6 | 52.8 | 0.006 |  |
Bilateral parietal | 1.2031 | 0.523 (0.348–0.698) | 54.5 | 50.0 | 0.006 |  |
Bilateral temporal | 1.1257 | 0.523 (0.348–0.698) | 54.5 | 50.0 | 0.006 |  |
L) Precuneus | 1.244 | 0.596 (0.426–0.766) | 63.6 | 55.6 | 0.006 |  |
R) Precuneus | 1.2433 | 0.537 (0.362–0.712) | 54.5 | 52.8 | 0.006 |  |
L) Posterior cingulate | 1.3054 | 0.537 (0.362–0.712) | 54.5 | 52.8 | 0.006 |  |
R) Posterior cingulate | 1.3244 | 0.537 (0.362–0.712) | 54.5 | 52.8 | 0.006 |  |
FBB composite | 1.1759 | 0.582 (0.412–0.753) | 52.8 | 63.6 | 0.006 |  |
DeLong’s test for the two correlated ROC curves | ||||||
 Model 1 | ||||||
  Bilateral frontal, left precuneus |  | 0.664 (0.487–0.841) | 27.3 | 94.4 | < 0.001 | 0.293 |
 Model 2 (whole VOIs) | ||||||
  Bilateral frontal, temporal, parietal, posterior cingulate, precuneus, FBB composite |  | 0.732 (0.567–0.893) | 72.7 | 61.1 | <0.001 | |