From: Grey matter changes on brain MRI in subjective cognitive decline: a systematic review
 | Sample | Age | Sample recruitment | Study type | Main results | ||
---|---|---|---|---|---|---|---|
Control | SCI | Control | SCI | ||||
Eliassen et al. (2017) [61] | - | 38 | - | 59 (8.3) | Memory clinic | Prospective | Focal cortical thinning was found in the bilateral EC in SCD compared with HC. |
Fan et al. (2017) | 34 | 43 | 67.8 (7.4) | 66.1 (7.0) | Memory clinic | Prospective | Focal cortical thinning was found in the left parahippocampal, perirhinal and EC and in the right parahippocampal and perirhinal in SCD compared with HC. |
Hong et al. (2014) [62] | 23 | 47 | 66.4 (6.9) | 63.2 (7.5) | Memory clinic | Prospective | No significant differences were found between SCD and HC. |
Lauriola et al. (2017) [63] | 38 | 32 | 64.0 (5.1) | 64.8 (6.3) | Other | Prospective | Focal cortical thinning was found in the left medial orbitofrontal in SCD compared with HC. |
Marcotte et al. (2019) [44] | 29 | 68 | 70 (6.3) | 71 (6.4) | Other | Prospective | No significant differences were found between SCD and HC. |
Meiberth et al. (2015) [64] | 69 | 41 | 66.1 (6.9) | 68.9 (7.2) | Memory clinic | Prospective | Focal cortical thinning was found in left EC in SCD compared with HC. |
Niemantsverdriet et al. (2018) [65] | 93 | 102 | 67.3(8.5) | 68.6 (9.8) | Memory clinic | Retrospective | No significant differences were found between SCD and HC. |
Schultz et al. (2015) [49] | 184 | 77 | 54.33 (6.10) | 54.41 (6.44) | Other | Prospective | Focal cortical thinning was found in the EC, fusiform, posterior cingulate and inferior parietal cortex in SCD compared with HC. |
Selnes et al. (2012) [13] | 21 | 16 | 62 (49-77) | 59.2 (45-71) | Memory clinic | Prospective | No significant differences were found between SCD and HC. |