Table 1 Main features of published clinical studies using voxel-based analysis comparing SCD with HC: sample characteristics, study type and outcomes
From: Grey matter changes on brain MRI in subjective cognitive decline: a systematic review
Reference | Sample | Age | Sample recruitment | Study type | Main results | ||
|---|---|---|---|---|---|---|---|
Control | SCI | Control | SCI | ||||
45 | 49 | 74.9 (7.1) | 73.9 (7.2) | Other | Prospective | Regional atrophy was found in the bilateral superior frontal sulci in SCD compared with HC. | |
Choi et al. (2015) [18] | 33 | 36 | 63.9 (7.5) | 64.6 (7.7) | Memory clinic | Retrospective | Regional atrophy was found in the left superior and medial frontal gyri, left superior and inferior parietal lobules and right precuneus and insula in SCD compared with HC. |
Dong et al. (2020) [19] | 67 | 63 | 65.3 (5.1) | 65.8(5.0) | Other | Retrospective | No significant differences were found between SCD and HC. |
Erk et al. (2011) [20] | 20 | 19 | 66.8 (5.4) | 68.4 (5.7) | Memory clinic | Retrospective | No significant differences were found between SCD and HC. |
29 | 25 | 71.3 (3.4) | 71.4 (9.2) | Memory clinic | Prospective | Regional atrophy was found in the right hippocampus and amygdala, bilateral ACC, mPFC, cuneus, precuneus and precentral gyrus in SCD compared with HC. | |
Hong et al. (2015) [23] | 28 | 28 | 70.6 (6.48) | 70.9 (6.23) | Memory clinic | Prospective | Regional atrophy was found in the left orbitofrontal gyrus, inferior frontal gyrus, right calcarine gyrus, precuneus, lingual gyrus, inferior temporal gyrus and other mid-cingulate areas in SCD compared with HC. |
Kiuchi et al. (2014) [11] | 41 | 28 | 75.2 (5.3) | 70.5 (7.3) | Memory clinic | Prospective | No significant differences were found between SCD and HC. |
Liang et al. (2020) [24] | 32 | 35 | 63.03 (5.4) | 64.94 (5.95) | Other | Prospective | Regional atrophy was found in the bilateral hippocampal tails and increased volume was found in the bilateral paracentral lobules in SCD compared with HC. |
Parker et al. (2020) [25] | 23 | 23 | 74.3 (5.0) | 72.9 (5.4) | Other | Retrospective | No significant differences were found between SCD and HC. |
Perrotin et al. (2015) [26] | 40 | 17 | 69.35 (6.37) | 69.12 (8.52) | Memory clinic | Prospective | Regional atrophy was found in the hippocampus (CA1) in SCD compared with HC. |
Perrotin et al. (2017) [12] | 35 | 63 | 65.6 (8.6) | 67.6 (7.7)* 70.8 (7.5)* | Other | Prospective | No significant differences were found between SCD and HC. |
Saykin et al. (2006) [27] | 40 | 40 | 71 (5.1) | 73.3 (6) | Other | Prospective | Regional atrophy was found in the bilateral frontal lobe (top), right hippocampus (middle) and left hippocampus in SCD compared with HC. |
Scheef et al. (2012) [28] | 56 | 31 | 66.4 (7.2) | 67.6 (6.2) | Memory clinic | Prospective | Regional atrophy was found in the right hippocampus in SCD compared with HC. |
Sun et al. (2016) [29] | 61 | 25 | 64.11 (8.59) | 65.52 (6.12) | Memory clinic | Prospective | No significant differences were found between SCD and HC. |
Xue et al. (2020) [30] | 28 | 19 | 72.66 (4.42) | 71.95 (5.09) | Other | Retrospective | No significant differences were found between SCD and HC. |