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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementia

Fig. 3

Bar graphs representing the relative contribution of each biomarker to the overall explained variance in performance of PSEN1 E280A mutation carriers on A the Mini-Mental State Exam (MMSE) score and B the CERAD Word List Learning Composite score. The relative contribution of each regressor is quantified using the LMG metric computed with the R package “relaimpo” (U. Grömping, 2006). Lines represent 95% confidence intervals after 1000 bootstrapping replications. CSF, cerebrospinal fluid; ptau, phospho-tau; SPL CT, superior parietal lobe cortical thickness; nWMH Vol., normalized white matter hyperintensity volume. *p < 0.05, **p < 0.01, ***p < 0.001

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