Fig. 3From: White matter hyperintensities are a prominent feature of autosomal dominant Alzheimer’s disease that emerge prior to dementiaBar graphs representing the relative contribution of each biomarker to the overall explained variance in performance of PSEN1 E280A mutation carriers on A the Mini-Mental State Exam (MMSE) score and B the CERAD Word List Learning Composite score. The relative contribution of each regressor is quantified using the LMG metric computed with the R package “relaimpo” (U. Grömping, 2006). Lines represent 95% confidence intervals after 1000 bootstrapping replications. CSF, cerebrospinal fluid; ptau, phospho-tau; SPL CT, superior parietal lobe cortical thickness; nWMH Vol., normalized white matter hyperintensity volume. *p < 0.05, **p < 0.01, ***p < 0.001Back to article page