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Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer’s disease

Fig. 8

NIR light and Aβ are the metabolic regulators of microglial phenotype and function. The proposed metabolic processes are based on the research in this article and from research papers focused on microglia and referenced in the text. Arg, arginase; CCO, cytochrome C oxidase; GLUT, glucose transport; G6PD, glucose-6-phosphate dehydrogenase; I-V, complexes CI-CV of electron transport chain; iNOS, inducible nitric oxide synthase; NADPH/NADP+, nicotinamide adenine dinucleotide phosphate; NO, nitric oxide; NOX, NADPH oxidase; OXPHOS, oxidative phosphorylation; PPP, pentose phosphate pathway; ROS, reactive oxygen species; Src, Src-family protein kinases; TCA, tricarboxylic acid; TLR, Toll-like receptor

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