Fig. 2

Associations between LS7 scores and CSF Aβ − and tau-related biomarkers. Multiple linear regression models were used to examine the associations between the total LS7 scores (A–D), subscales of biological metrics (E–H), and behavior metrics (I–L) with cerebrospinal fluid (CSF) Aβ42, Aβ42/40, p-tau181, and t-tau biomarkers, adjusting for age, sex, years of education, and APOE ɛ4 allele statuses. LS7, Life’s Simple 7; CSF, cerebrospinal fluid; Aβ, amyloid beta; P-tau181, phosphorylated tau181; T-tau, total tau